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Association of Typical Toxic Heavy Metals with Schizophrenia

Toxic heavy metals (THMs) are contaminants commonly found in the environment. Although a large number of studies have demonstrated their damage to the biological functions of the human being, their potential associations with the risk of developing schizophrenia remain controversial. In this study,...

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Detalles Bibliográficos
Autores principales: Ma, Jiahui, Yan, Lailai, Guo, Tongjun, Yang, Siyu, Guo, Chen, Liu, Yaqiong, Xie, Qing, Wang, Jingyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6862006/
https://www.ncbi.nlm.nih.gov/pubmed/31671526
http://dx.doi.org/10.3390/ijerph16214200
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author Ma, Jiahui
Yan, Lailai
Guo, Tongjun
Yang, Siyu
Guo, Chen
Liu, Yaqiong
Xie, Qing
Wang, Jingyu
author_facet Ma, Jiahui
Yan, Lailai
Guo, Tongjun
Yang, Siyu
Guo, Chen
Liu, Yaqiong
Xie, Qing
Wang, Jingyu
author_sort Ma, Jiahui
collection PubMed
description Toxic heavy metals (THMs) are contaminants commonly found in the environment. Although a large number of studies have demonstrated their damage to the biological functions of the human being, their potential associations with the risk of developing schizophrenia remain controversial. In this study, we investigated the associations between four THMs (chromium (Cr), cadmium (Cd), lead (Pb) and arsenic (As)) in serum and the risk of schizophrenia. In total, 95 patients with schizophrenia (cases) and 95 normal subjects (controls) were recruited from Hebei Province, China. The serum concentrations of the 4 THMs were analyzed by inductively coupled plasma mass spectrometry (ICP-MS). A higher concentration of Pb was found significantly associated with an elevated risk of schizophrenia (OR = 3.146; 95%CI: 1.238–7.994, p = 0.016), while significant association for the other three THMs were not observed. Besides, significant correlations were found between the metabolic biomarkers and the concentrations of Pb and As, respectively. In order to further characterize the association between these THMs and schizophrenia with greater statistical power, we conducted meta-analysis by including 538 cases and 1040 controls from the current study and 5 available datasets published from 2002 to 2018. Using a random-effect model, Cr was significantly associated with schizophrenia (SMD = 0.3246; 95%CI: 0.0166–0.6326, p < 0.01). Overall, this study suggested that higher levels of Pb and Cr may be one of the factors associated with an elevated risk of schizophrenia.
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spelling pubmed-68620062019-12-05 Association of Typical Toxic Heavy Metals with Schizophrenia Ma, Jiahui Yan, Lailai Guo, Tongjun Yang, Siyu Guo, Chen Liu, Yaqiong Xie, Qing Wang, Jingyu Int J Environ Res Public Health Article Toxic heavy metals (THMs) are contaminants commonly found in the environment. Although a large number of studies have demonstrated their damage to the biological functions of the human being, their potential associations with the risk of developing schizophrenia remain controversial. In this study, we investigated the associations between four THMs (chromium (Cr), cadmium (Cd), lead (Pb) and arsenic (As)) in serum and the risk of schizophrenia. In total, 95 patients with schizophrenia (cases) and 95 normal subjects (controls) were recruited from Hebei Province, China. The serum concentrations of the 4 THMs were analyzed by inductively coupled plasma mass spectrometry (ICP-MS). A higher concentration of Pb was found significantly associated with an elevated risk of schizophrenia (OR = 3.146; 95%CI: 1.238–7.994, p = 0.016), while significant association for the other three THMs were not observed. Besides, significant correlations were found between the metabolic biomarkers and the concentrations of Pb and As, respectively. In order to further characterize the association between these THMs and schizophrenia with greater statistical power, we conducted meta-analysis by including 538 cases and 1040 controls from the current study and 5 available datasets published from 2002 to 2018. Using a random-effect model, Cr was significantly associated with schizophrenia (SMD = 0.3246; 95%CI: 0.0166–0.6326, p < 0.01). Overall, this study suggested that higher levels of Pb and Cr may be one of the factors associated with an elevated risk of schizophrenia. MDPI 2019-10-30 2019-11 /pmc/articles/PMC6862006/ /pubmed/31671526 http://dx.doi.org/10.3390/ijerph16214200 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ma, Jiahui
Yan, Lailai
Guo, Tongjun
Yang, Siyu
Guo, Chen
Liu, Yaqiong
Xie, Qing
Wang, Jingyu
Association of Typical Toxic Heavy Metals with Schizophrenia
title Association of Typical Toxic Heavy Metals with Schizophrenia
title_full Association of Typical Toxic Heavy Metals with Schizophrenia
title_fullStr Association of Typical Toxic Heavy Metals with Schizophrenia
title_full_unstemmed Association of Typical Toxic Heavy Metals with Schizophrenia
title_short Association of Typical Toxic Heavy Metals with Schizophrenia
title_sort association of typical toxic heavy metals with schizophrenia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6862006/
https://www.ncbi.nlm.nih.gov/pubmed/31671526
http://dx.doi.org/10.3390/ijerph16214200
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