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Does Croton Argyrophyllus Extract Has an Effect on Muscle Damage and Lipid Peroxidation in Rats Submitted to High Intensity Strength Exercise?

Many species of the genus Croton have been used for anti-inflammatory, antiproliferative, antidiabetic, and antitumor purposes. The objective was to evaluate the effect of a hydroethanolic extract (HEE) from the inner bark of Croton argyrophyllus (Euphorbiaceae) on muscle damage and oxidative stress...

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Autores principales: de Araújo, Silvan Silva, Aidar, Felipe José, de Matos, Dihogo Gama, dos Santos, Jymmys Lopes, Vieira Souza, Lúcio Marques, da Silva, Albená Nunes, dos Santos, Rodrigo Miguel, Marçal, Anderson Carlos, Mourão, Daniella Mota, Júnior, Amário Lessa, Durães, Geraldo Magela, Carneiro, André Luiz Gomes, da Silva, Rodrigo Gonçalves, Teixeira, Mauro Martins, Estevam, Charles dos Santos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6862100/
https://www.ncbi.nlm.nih.gov/pubmed/31683746
http://dx.doi.org/10.3390/ijerph16214237
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author de Araújo, Silvan Silva
Aidar, Felipe José
de Matos, Dihogo Gama
dos Santos, Jymmys Lopes
Vieira Souza, Lúcio Marques
da Silva, Albená Nunes
dos Santos, Rodrigo Miguel
Marçal, Anderson Carlos
Mourão, Daniella Mota
Júnior, Amário Lessa
Durães, Geraldo Magela
Carneiro, André Luiz Gomes
da Silva, Rodrigo Gonçalves
Teixeira, Mauro Martins
Estevam, Charles dos Santos
author_facet de Araújo, Silvan Silva
Aidar, Felipe José
de Matos, Dihogo Gama
dos Santos, Jymmys Lopes
Vieira Souza, Lúcio Marques
da Silva, Albená Nunes
dos Santos, Rodrigo Miguel
Marçal, Anderson Carlos
Mourão, Daniella Mota
Júnior, Amário Lessa
Durães, Geraldo Magela
Carneiro, André Luiz Gomes
da Silva, Rodrigo Gonçalves
Teixeira, Mauro Martins
Estevam, Charles dos Santos
author_sort de Araújo, Silvan Silva
collection PubMed
description Many species of the genus Croton have been used for anti-inflammatory, antiproliferative, antidiabetic, and antitumor purposes. The objective was to evaluate the effect of a hydroethanolic extract (HEE) from the inner bark of Croton argyrophyllus (Euphorbiaceae) on muscle damage and oxidative stress in rats after high intensity exercise. The animals were divided into four groups: (i) the sedentary group (SV; n = 7), (ii) the exercise vehicle group (EV, n = 7), (iii) the sedentary group HEE (SHG; n = 7) composed of sedentary animals and treated with the hydroethanolic extract of C. argyrophyllus (200 mg/kg, v.o.), and (iv) the HEE exercise group (HEE; n = 7) composed of animals submitted to resistance exercise (RE) and treated with the hydroethanolic extract of C. argyrophyllus (200 mg/kg, v.o.). In the 2,2-Diphenyl-1-picrylhydrazyl (DPPH) test, the HEE showed lower values of inhibition potential (IP%) at 39.79% compared to gallic acid, 87.61%, and lipoperoxidation inhibition at 27.4% (100 µg/mL) or 28.6% (200 µg/mL) (p < 0.001). There was inhibition in free radicals in vivo. The HEE of C. argyrophyllus partially reduced the biomarkers of oxidative stress in muscle tissue and muscular damage (creatine kinase (CK) and Lactate Dehydrogenase (LDH)) (p < 0.05) in rats, and in this sense it can be an aid to the recovery process after exhaustive efforts.
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spelling pubmed-68621002019-12-05 Does Croton Argyrophyllus Extract Has an Effect on Muscle Damage and Lipid Peroxidation in Rats Submitted to High Intensity Strength Exercise? de Araújo, Silvan Silva Aidar, Felipe José de Matos, Dihogo Gama dos Santos, Jymmys Lopes Vieira Souza, Lúcio Marques da Silva, Albená Nunes dos Santos, Rodrigo Miguel Marçal, Anderson Carlos Mourão, Daniella Mota Júnior, Amário Lessa Durães, Geraldo Magela Carneiro, André Luiz Gomes da Silva, Rodrigo Gonçalves Teixeira, Mauro Martins Estevam, Charles dos Santos Int J Environ Res Public Health Article Many species of the genus Croton have been used for anti-inflammatory, antiproliferative, antidiabetic, and antitumor purposes. The objective was to evaluate the effect of a hydroethanolic extract (HEE) from the inner bark of Croton argyrophyllus (Euphorbiaceae) on muscle damage and oxidative stress in rats after high intensity exercise. The animals were divided into four groups: (i) the sedentary group (SV; n = 7), (ii) the exercise vehicle group (EV, n = 7), (iii) the sedentary group HEE (SHG; n = 7) composed of sedentary animals and treated with the hydroethanolic extract of C. argyrophyllus (200 mg/kg, v.o.), and (iv) the HEE exercise group (HEE; n = 7) composed of animals submitted to resistance exercise (RE) and treated with the hydroethanolic extract of C. argyrophyllus (200 mg/kg, v.o.). In the 2,2-Diphenyl-1-picrylhydrazyl (DPPH) test, the HEE showed lower values of inhibition potential (IP%) at 39.79% compared to gallic acid, 87.61%, and lipoperoxidation inhibition at 27.4% (100 µg/mL) or 28.6% (200 µg/mL) (p < 0.001). There was inhibition in free radicals in vivo. The HEE of C. argyrophyllus partially reduced the biomarkers of oxidative stress in muscle tissue and muscular damage (creatine kinase (CK) and Lactate Dehydrogenase (LDH)) (p < 0.05) in rats, and in this sense it can be an aid to the recovery process after exhaustive efforts. MDPI 2019-10-31 2019-11 /pmc/articles/PMC6862100/ /pubmed/31683746 http://dx.doi.org/10.3390/ijerph16214237 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
de Araújo, Silvan Silva
Aidar, Felipe José
de Matos, Dihogo Gama
dos Santos, Jymmys Lopes
Vieira Souza, Lúcio Marques
da Silva, Albená Nunes
dos Santos, Rodrigo Miguel
Marçal, Anderson Carlos
Mourão, Daniella Mota
Júnior, Amário Lessa
Durães, Geraldo Magela
Carneiro, André Luiz Gomes
da Silva, Rodrigo Gonçalves
Teixeira, Mauro Martins
Estevam, Charles dos Santos
Does Croton Argyrophyllus Extract Has an Effect on Muscle Damage and Lipid Peroxidation in Rats Submitted to High Intensity Strength Exercise?
title Does Croton Argyrophyllus Extract Has an Effect on Muscle Damage and Lipid Peroxidation in Rats Submitted to High Intensity Strength Exercise?
title_full Does Croton Argyrophyllus Extract Has an Effect on Muscle Damage and Lipid Peroxidation in Rats Submitted to High Intensity Strength Exercise?
title_fullStr Does Croton Argyrophyllus Extract Has an Effect on Muscle Damage and Lipid Peroxidation in Rats Submitted to High Intensity Strength Exercise?
title_full_unstemmed Does Croton Argyrophyllus Extract Has an Effect on Muscle Damage and Lipid Peroxidation in Rats Submitted to High Intensity Strength Exercise?
title_short Does Croton Argyrophyllus Extract Has an Effect on Muscle Damage and Lipid Peroxidation in Rats Submitted to High Intensity Strength Exercise?
title_sort does croton argyrophyllus extract has an effect on muscle damage and lipid peroxidation in rats submitted to high intensity strength exercise?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6862100/
https://www.ncbi.nlm.nih.gov/pubmed/31683746
http://dx.doi.org/10.3390/ijerph16214237
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