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Ginseng berry aqueous extract prevents scopolamine-induced memory impairment in mice

Ginseng berry exhibits a diverse range of pharmacological activities. The present study aimed to examine the neuroprotective effects of ginseng berry aqueous extract (GBE) against oxidative stress and to assess the impact of GBE on memory impairment in mice. In HT-22 cells, GBE pretreatment signific...

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Autores principales: Hu, Jin Ryul, Chun, Yoon Seok, Kim, Jong Kyu, Cho, Il Je, Ku, Sae Kwang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6862129/
https://www.ncbi.nlm.nih.gov/pubmed/31772634
http://dx.doi.org/10.3892/etm.2019.8090
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author Hu, Jin Ryul
Chun, Yoon Seok
Kim, Jong Kyu
Cho, Il Je
Ku, Sae Kwang
author_facet Hu, Jin Ryul
Chun, Yoon Seok
Kim, Jong Kyu
Cho, Il Je
Ku, Sae Kwang
author_sort Hu, Jin Ryul
collection PubMed
description Ginseng berry exhibits a diverse range of pharmacological activities. The present study aimed to examine the neuroprotective effects of ginseng berry aqueous extract (GBE) against oxidative stress and to assess the impact of GBE on memory impairment in mice. In HT-22 cells, GBE pretreatment significantly inhibited glutamate- and hydrogen peroxide-mediated cytotoxicity in a concentration-dependent manner, while treatment with up to 100 µg/ml GBE alone did not change cell viability. In a murine model of scopolamine (SCP)-induced memory impairment, results from the passive avoidance test and the Morris water maze test indicated that GBE administration for 4 weeks prolonged step-through latency time and shortened escape latency time, suggesting that GBE can attenuate deficits in long-term memory induced by SCP. Additionally, GBE prevented SCP-induced reductions in acetylcholine by decreasing acetylcholinesterase activity and upregulating choline acetyltransferase mRNA levels in the hippocampus. GBE mitigated SCP-mediated mRNA decreases in brain-derived neurotrophic factor levels and its associated signaling molecules. Furthermore, GBE administration significantly suppressed malondialdehyde production and increased glutathione levels, catalase activity and superoxide dismutase activity in SCP-induced memory impaired mice. Therefore, the results of the current study indicated that ginseng berry may be a potential candidate for treating or preventing memory deficits that are associated with neurodegenerative disorders.
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spelling pubmed-68621292019-11-26 Ginseng berry aqueous extract prevents scopolamine-induced memory impairment in mice Hu, Jin Ryul Chun, Yoon Seok Kim, Jong Kyu Cho, Il Je Ku, Sae Kwang Exp Ther Med Articles Ginseng berry exhibits a diverse range of pharmacological activities. The present study aimed to examine the neuroprotective effects of ginseng berry aqueous extract (GBE) against oxidative stress and to assess the impact of GBE on memory impairment in mice. In HT-22 cells, GBE pretreatment significantly inhibited glutamate- and hydrogen peroxide-mediated cytotoxicity in a concentration-dependent manner, while treatment with up to 100 µg/ml GBE alone did not change cell viability. In a murine model of scopolamine (SCP)-induced memory impairment, results from the passive avoidance test and the Morris water maze test indicated that GBE administration for 4 weeks prolonged step-through latency time and shortened escape latency time, suggesting that GBE can attenuate deficits in long-term memory induced by SCP. Additionally, GBE prevented SCP-induced reductions in acetylcholine by decreasing acetylcholinesterase activity and upregulating choline acetyltransferase mRNA levels in the hippocampus. GBE mitigated SCP-mediated mRNA decreases in brain-derived neurotrophic factor levels and its associated signaling molecules. Furthermore, GBE administration significantly suppressed malondialdehyde production and increased glutathione levels, catalase activity and superoxide dismutase activity in SCP-induced memory impaired mice. Therefore, the results of the current study indicated that ginseng berry may be a potential candidate for treating or preventing memory deficits that are associated with neurodegenerative disorders. D.A. Spandidos 2019-12 2019-10-08 /pmc/articles/PMC6862129/ /pubmed/31772634 http://dx.doi.org/10.3892/etm.2019.8090 Text en Copyright: © Hu et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Hu, Jin Ryul
Chun, Yoon Seok
Kim, Jong Kyu
Cho, Il Je
Ku, Sae Kwang
Ginseng berry aqueous extract prevents scopolamine-induced memory impairment in mice
title Ginseng berry aqueous extract prevents scopolamine-induced memory impairment in mice
title_full Ginseng berry aqueous extract prevents scopolamine-induced memory impairment in mice
title_fullStr Ginseng berry aqueous extract prevents scopolamine-induced memory impairment in mice
title_full_unstemmed Ginseng berry aqueous extract prevents scopolamine-induced memory impairment in mice
title_short Ginseng berry aqueous extract prevents scopolamine-induced memory impairment in mice
title_sort ginseng berry aqueous extract prevents scopolamine-induced memory impairment in mice
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6862129/
https://www.ncbi.nlm.nih.gov/pubmed/31772634
http://dx.doi.org/10.3892/etm.2019.8090
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