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Hybrid Systems Based on Talc and Chitosan for Controlled Drug Release

Inorganic matrices and biopolymers have been widely used in pharmaceutical fields. They show properties such as biocompatibility, incorporation capacity, and controlled drug release, which can become more attractive if they are combined to form hybrid materials. This work proposes the synthesis of n...

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Autores principales: Lima, Luciano C. B., Coelho, Caio C., Silva, Fabrícia C., Meneguin, Andréia B., Barud, Hernane S., Bezerra, Roosevelt D. S., Viseras, Cesar, Osajima, Josy A., Silva-Filho, Edson C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6862275/
https://www.ncbi.nlm.nih.gov/pubmed/31694168
http://dx.doi.org/10.3390/ma12213634
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author Lima, Luciano C. B.
Coelho, Caio C.
Silva, Fabrícia C.
Meneguin, Andréia B.
Barud, Hernane S.
Bezerra, Roosevelt D. S.
Viseras, Cesar
Osajima, Josy A.
Silva-Filho, Edson C.
author_facet Lima, Luciano C. B.
Coelho, Caio C.
Silva, Fabrícia C.
Meneguin, Andréia B.
Barud, Hernane S.
Bezerra, Roosevelt D. S.
Viseras, Cesar
Osajima, Josy A.
Silva-Filho, Edson C.
author_sort Lima, Luciano C. B.
collection PubMed
description Inorganic matrices and biopolymers have been widely used in pharmaceutical fields. They show properties such as biocompatibility, incorporation capacity, and controlled drug release, which can become more attractive if they are combined to form hybrid materials. This work proposes the synthesis of new drug delivery systems (DDS) based on magnesium phyllosilicate (Talc) obtained by the sol–gel route method, the biopolymer chitosan (Ch), and the inorganic-organic hybrid formed between this matrix (Talc + Ch), obtained using glutaraldehyde as a crosslink agent, and to study their incorporation/release capacity of amiloride as a model drug. The systems were characterized by X-ray diffraction (XRD), Therma analysis TG/DTG, and Fourier-transform infrared spectroscopy (FTIR) that supported the DDS’s formation. The hybrid showed a better drug incorporation capacity compared to the precursors, with a loading of 55.74, 49.53, and 4.71 mg g(−1) for Talc + Ch, Talc, and Ch, respectively. The release assays were performed on a Hanson Research SR-8 Plus dissolver using apparatus I (basket), set to guarantee the sink conditions. The in vitro release tests showed a prolongation of the release rates of this drug for at least 4 h. This result proposes that the systems implies the slow and gradual release of the active substance, favoring the maintenance of the plasma concentration within a therapeutic window.
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spelling pubmed-68622752019-12-05 Hybrid Systems Based on Talc and Chitosan for Controlled Drug Release Lima, Luciano C. B. Coelho, Caio C. Silva, Fabrícia C. Meneguin, Andréia B. Barud, Hernane S. Bezerra, Roosevelt D. S. Viseras, Cesar Osajima, Josy A. Silva-Filho, Edson C. Materials (Basel) Article Inorganic matrices and biopolymers have been widely used in pharmaceutical fields. They show properties such as biocompatibility, incorporation capacity, and controlled drug release, which can become more attractive if they are combined to form hybrid materials. This work proposes the synthesis of new drug delivery systems (DDS) based on magnesium phyllosilicate (Talc) obtained by the sol–gel route method, the biopolymer chitosan (Ch), and the inorganic-organic hybrid formed between this matrix (Talc + Ch), obtained using glutaraldehyde as a crosslink agent, and to study their incorporation/release capacity of amiloride as a model drug. The systems were characterized by X-ray diffraction (XRD), Therma analysis TG/DTG, and Fourier-transform infrared spectroscopy (FTIR) that supported the DDS’s formation. The hybrid showed a better drug incorporation capacity compared to the precursors, with a loading of 55.74, 49.53, and 4.71 mg g(−1) for Talc + Ch, Talc, and Ch, respectively. The release assays were performed on a Hanson Research SR-8 Plus dissolver using apparatus I (basket), set to guarantee the sink conditions. The in vitro release tests showed a prolongation of the release rates of this drug for at least 4 h. This result proposes that the systems implies the slow and gradual release of the active substance, favoring the maintenance of the plasma concentration within a therapeutic window. MDPI 2019-11-05 /pmc/articles/PMC6862275/ /pubmed/31694168 http://dx.doi.org/10.3390/ma12213634 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lima, Luciano C. B.
Coelho, Caio C.
Silva, Fabrícia C.
Meneguin, Andréia B.
Barud, Hernane S.
Bezerra, Roosevelt D. S.
Viseras, Cesar
Osajima, Josy A.
Silva-Filho, Edson C.
Hybrid Systems Based on Talc and Chitosan for Controlled Drug Release
title Hybrid Systems Based on Talc and Chitosan for Controlled Drug Release
title_full Hybrid Systems Based on Talc and Chitosan for Controlled Drug Release
title_fullStr Hybrid Systems Based on Talc and Chitosan for Controlled Drug Release
title_full_unstemmed Hybrid Systems Based on Talc and Chitosan for Controlled Drug Release
title_short Hybrid Systems Based on Talc and Chitosan for Controlled Drug Release
title_sort hybrid systems based on talc and chitosan for controlled drug release
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6862275/
https://www.ncbi.nlm.nih.gov/pubmed/31694168
http://dx.doi.org/10.3390/ma12213634
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