The Association and Significance of p53 in Gynecologic Cancers: The Potential of Targeted Therapy

Dysfunction of p53 is observed in the many malignant tumors. In cervical cancer, p53 is inactivated by degradation through the complex with human papilloma virus (HPV) oncoprotein E6 and E6-associated protein (E6AP), an E3 ubiquitin protein ligase. In endometrial cancer, overexpression of p53 in imm...

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Detalles Bibliográficos
Autores principales: Nakamura, Mitsuhiro, Obata, Takeshi, Daikoku, Takiko, Fujiwara, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6862296/
https://www.ncbi.nlm.nih.gov/pubmed/31689961
http://dx.doi.org/10.3390/ijms20215482

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6862296/
https://www.ncbi.nlm.nih.gov/pubmed/31689961
http://dx.doi.org/10.3390/ijms20215482

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