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Gut Microbiota Profiles Differ among Individuals Depending on Their Region of Origin: An Italian Pilot Study
Background and aims: Microbiota heterogeneity among humans is mainly due to genetic background, age, dietary habits, lifestyle and local environments. In this study we investigated whether the gut microbiota profile of Italian healthy volunteers could differ based on their geographical origin. Mater...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6862301/ https://www.ncbi.nlm.nih.gov/pubmed/31652705 http://dx.doi.org/10.3390/ijerph16214065 |
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author | Fontana, Andrea Panebianco, Concetta Picchianti-Diamanti, Andrea Laganà, Bruno Cavalieri, Duccio Potenza, Adele Pracella, Riccardo Binda, Elena Copetti, Massimiliano Pazienza, Valerio |
author_facet | Fontana, Andrea Panebianco, Concetta Picchianti-Diamanti, Andrea Laganà, Bruno Cavalieri, Duccio Potenza, Adele Pracella, Riccardo Binda, Elena Copetti, Massimiliano Pazienza, Valerio |
author_sort | Fontana, Andrea |
collection | PubMed |
description | Background and aims: Microbiota heterogeneity among humans is mainly due to genetic background, age, dietary habits, lifestyle and local environments. In this study we investigated whether the gut microbiota profile of Italian healthy volunteers could differ based on their geographical origin. Materials and Methods: 16S rRNA gene sequencing was employed to analyze the gut microbiota of 31 healthy volunteers from three different Italian regions: Apulia (South), Lazio (Center) and Lombardy (North). Results: Differences in microbiota composition were detected when the study participants were grouped by their region of origin and when they were classified based on age classes (p-values < 0.05). Also species richness was significantly different both according to Italian Regions (median richness: 177.8 vs. 140.7 vs. 168.0 in Apulia, Lazio and Lombardy; p < 0.001) and according to age classes (median richness: 140.1 vs. 177.8 vs. 160.0 in subjects < 32, 32–41 and > 41 years; p < 0.001), whereas the Shannon index and beta diversity did not change. Conclusions: This study identified differences in the gut microbiota composition and richness among individuals with the same ethnicity coming from three different Italian regions. Our results underline the importance of studies on population-specific variations in human microbiota composition leading to geographically tailored approaches to microbiota engineering. |
format | Online Article Text |
id | pubmed-6862301 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-68623012019-12-05 Gut Microbiota Profiles Differ among Individuals Depending on Their Region of Origin: An Italian Pilot Study Fontana, Andrea Panebianco, Concetta Picchianti-Diamanti, Andrea Laganà, Bruno Cavalieri, Duccio Potenza, Adele Pracella, Riccardo Binda, Elena Copetti, Massimiliano Pazienza, Valerio Int J Environ Res Public Health Article Background and aims: Microbiota heterogeneity among humans is mainly due to genetic background, age, dietary habits, lifestyle and local environments. In this study we investigated whether the gut microbiota profile of Italian healthy volunteers could differ based on their geographical origin. Materials and Methods: 16S rRNA gene sequencing was employed to analyze the gut microbiota of 31 healthy volunteers from three different Italian regions: Apulia (South), Lazio (Center) and Lombardy (North). Results: Differences in microbiota composition were detected when the study participants were grouped by their region of origin and when they were classified based on age classes (p-values < 0.05). Also species richness was significantly different both according to Italian Regions (median richness: 177.8 vs. 140.7 vs. 168.0 in Apulia, Lazio and Lombardy; p < 0.001) and according to age classes (median richness: 140.1 vs. 177.8 vs. 160.0 in subjects < 32, 32–41 and > 41 years; p < 0.001), whereas the Shannon index and beta diversity did not change. Conclusions: This study identified differences in the gut microbiota composition and richness among individuals with the same ethnicity coming from three different Italian regions. Our results underline the importance of studies on population-specific variations in human microbiota composition leading to geographically tailored approaches to microbiota engineering. MDPI 2019-10-23 2019-11 /pmc/articles/PMC6862301/ /pubmed/31652705 http://dx.doi.org/10.3390/ijerph16214065 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Fontana, Andrea Panebianco, Concetta Picchianti-Diamanti, Andrea Laganà, Bruno Cavalieri, Duccio Potenza, Adele Pracella, Riccardo Binda, Elena Copetti, Massimiliano Pazienza, Valerio Gut Microbiota Profiles Differ among Individuals Depending on Their Region of Origin: An Italian Pilot Study |
title | Gut Microbiota Profiles Differ among Individuals Depending on Their Region of Origin: An Italian Pilot Study |
title_full | Gut Microbiota Profiles Differ among Individuals Depending on Their Region of Origin: An Italian Pilot Study |
title_fullStr | Gut Microbiota Profiles Differ among Individuals Depending on Their Region of Origin: An Italian Pilot Study |
title_full_unstemmed | Gut Microbiota Profiles Differ among Individuals Depending on Their Region of Origin: An Italian Pilot Study |
title_short | Gut Microbiota Profiles Differ among Individuals Depending on Their Region of Origin: An Italian Pilot Study |
title_sort | gut microbiota profiles differ among individuals depending on their region of origin: an italian pilot study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6862301/ https://www.ncbi.nlm.nih.gov/pubmed/31652705 http://dx.doi.org/10.3390/ijerph16214065 |
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