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Gut Microbiota Profiles Differ among Individuals Depending on Their Region of Origin: An Italian Pilot Study

Background and aims: Microbiota heterogeneity among humans is mainly due to genetic background, age, dietary habits, lifestyle and local environments. In this study we investigated whether the gut microbiota profile of Italian healthy volunteers could differ based on their geographical origin. Mater...

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Autores principales: Fontana, Andrea, Panebianco, Concetta, Picchianti-Diamanti, Andrea, Laganà, Bruno, Cavalieri, Duccio, Potenza, Adele, Pracella, Riccardo, Binda, Elena, Copetti, Massimiliano, Pazienza, Valerio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6862301/
https://www.ncbi.nlm.nih.gov/pubmed/31652705
http://dx.doi.org/10.3390/ijerph16214065
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author Fontana, Andrea
Panebianco, Concetta
Picchianti-Diamanti, Andrea
Laganà, Bruno
Cavalieri, Duccio
Potenza, Adele
Pracella, Riccardo
Binda, Elena
Copetti, Massimiliano
Pazienza, Valerio
author_facet Fontana, Andrea
Panebianco, Concetta
Picchianti-Diamanti, Andrea
Laganà, Bruno
Cavalieri, Duccio
Potenza, Adele
Pracella, Riccardo
Binda, Elena
Copetti, Massimiliano
Pazienza, Valerio
author_sort Fontana, Andrea
collection PubMed
description Background and aims: Microbiota heterogeneity among humans is mainly due to genetic background, age, dietary habits, lifestyle and local environments. In this study we investigated whether the gut microbiota profile of Italian healthy volunteers could differ based on their geographical origin. Materials and Methods: 16S rRNA gene sequencing was employed to analyze the gut microbiota of 31 healthy volunteers from three different Italian regions: Apulia (South), Lazio (Center) and Lombardy (North). Results: Differences in microbiota composition were detected when the study participants were grouped by their region of origin and when they were classified based on age classes (p-values < 0.05). Also species richness was significantly different both according to Italian Regions (median richness: 177.8 vs. 140.7 vs. 168.0 in Apulia, Lazio and Lombardy; p < 0.001) and according to age classes (median richness: 140.1 vs. 177.8 vs. 160.0 in subjects < 32, 32–41 and > 41 years; p < 0.001), whereas the Shannon index and beta diversity did not change. Conclusions: This study identified differences in the gut microbiota composition and richness among individuals with the same ethnicity coming from three different Italian regions. Our results underline the importance of studies on population-specific variations in human microbiota composition leading to geographically tailored approaches to microbiota engineering.
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spelling pubmed-68623012019-12-05 Gut Microbiota Profiles Differ among Individuals Depending on Their Region of Origin: An Italian Pilot Study Fontana, Andrea Panebianco, Concetta Picchianti-Diamanti, Andrea Laganà, Bruno Cavalieri, Duccio Potenza, Adele Pracella, Riccardo Binda, Elena Copetti, Massimiliano Pazienza, Valerio Int J Environ Res Public Health Article Background and aims: Microbiota heterogeneity among humans is mainly due to genetic background, age, dietary habits, lifestyle and local environments. In this study we investigated whether the gut microbiota profile of Italian healthy volunteers could differ based on their geographical origin. Materials and Methods: 16S rRNA gene sequencing was employed to analyze the gut microbiota of 31 healthy volunteers from three different Italian regions: Apulia (South), Lazio (Center) and Lombardy (North). Results: Differences in microbiota composition were detected when the study participants were grouped by their region of origin and when they were classified based on age classes (p-values < 0.05). Also species richness was significantly different both according to Italian Regions (median richness: 177.8 vs. 140.7 vs. 168.0 in Apulia, Lazio and Lombardy; p < 0.001) and according to age classes (median richness: 140.1 vs. 177.8 vs. 160.0 in subjects < 32, 32–41 and > 41 years; p < 0.001), whereas the Shannon index and beta diversity did not change. Conclusions: This study identified differences in the gut microbiota composition and richness among individuals with the same ethnicity coming from three different Italian regions. Our results underline the importance of studies on population-specific variations in human microbiota composition leading to geographically tailored approaches to microbiota engineering. MDPI 2019-10-23 2019-11 /pmc/articles/PMC6862301/ /pubmed/31652705 http://dx.doi.org/10.3390/ijerph16214065 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Fontana, Andrea
Panebianco, Concetta
Picchianti-Diamanti, Andrea
Laganà, Bruno
Cavalieri, Duccio
Potenza, Adele
Pracella, Riccardo
Binda, Elena
Copetti, Massimiliano
Pazienza, Valerio
Gut Microbiota Profiles Differ among Individuals Depending on Their Region of Origin: An Italian Pilot Study
title Gut Microbiota Profiles Differ among Individuals Depending on Their Region of Origin: An Italian Pilot Study
title_full Gut Microbiota Profiles Differ among Individuals Depending on Their Region of Origin: An Italian Pilot Study
title_fullStr Gut Microbiota Profiles Differ among Individuals Depending on Their Region of Origin: An Italian Pilot Study
title_full_unstemmed Gut Microbiota Profiles Differ among Individuals Depending on Their Region of Origin: An Italian Pilot Study
title_short Gut Microbiota Profiles Differ among Individuals Depending on Their Region of Origin: An Italian Pilot Study
title_sort gut microbiota profiles differ among individuals depending on their region of origin: an italian pilot study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6862301/
https://www.ncbi.nlm.nih.gov/pubmed/31652705
http://dx.doi.org/10.3390/ijerph16214065
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