The Hedgehog Signaling Pathway in Ischemic Tissues

Hedgehog (Hh) proteins are prototypical morphogens known to regulate epithelial/mesenchymal interactions during embryonic development. In addition to its pivotal role in embryogenesis, the Hh signaling pathway may be recapitulated in post-natal life in a number of physiological and pathological cond...

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Autores principales: Giarretta, Igor, Gaetani, Eleonora, Bigossi, Margherita, Tondi, Paolo, Asahara, Takayuki, Pola, Roberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6862352/
https://www.ncbi.nlm.nih.gov/pubmed/31652910
http://dx.doi.org/10.3390/ijms20215270
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author Giarretta, Igor
Gaetani, Eleonora
Bigossi, Margherita
Tondi, Paolo
Asahara, Takayuki
Pola, Roberto
author_facet Giarretta, Igor
Gaetani, Eleonora
Bigossi, Margherita
Tondi, Paolo
Asahara, Takayuki
Pola, Roberto
author_sort Giarretta, Igor
collection PubMed
description Hedgehog (Hh) proteins are prototypical morphogens known to regulate epithelial/mesenchymal interactions during embryonic development. In addition to its pivotal role in embryogenesis, the Hh signaling pathway may be recapitulated in post-natal life in a number of physiological and pathological conditions, including ischemia. This review highlights the involvement of Hh signaling in ischemic tissue regeneration and angiogenesis, with particular attention to the heart, the brain, and the skeletal muscle. Updated information on the potential role of the Hh pathway as a therapeutic target in the ischemic condition is also presented.
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spelling pubmed-68623522019-12-05 The Hedgehog Signaling Pathway in Ischemic Tissues Giarretta, Igor Gaetani, Eleonora Bigossi, Margherita Tondi, Paolo Asahara, Takayuki Pola, Roberto Int J Mol Sci Review Hedgehog (Hh) proteins are prototypical morphogens known to regulate epithelial/mesenchymal interactions during embryonic development. In addition to its pivotal role in embryogenesis, the Hh signaling pathway may be recapitulated in post-natal life in a number of physiological and pathological conditions, including ischemia. This review highlights the involvement of Hh signaling in ischemic tissue regeneration and angiogenesis, with particular attention to the heart, the brain, and the skeletal muscle. Updated information on the potential role of the Hh pathway as a therapeutic target in the ischemic condition is also presented. MDPI 2019-10-24 /pmc/articles/PMC6862352/ /pubmed/31652910 http://dx.doi.org/10.3390/ijms20215270 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Giarretta, Igor
Gaetani, Eleonora
Bigossi, Margherita
Tondi, Paolo
Asahara, Takayuki
Pola, Roberto
The Hedgehog Signaling Pathway in Ischemic Tissues
title The Hedgehog Signaling Pathway in Ischemic Tissues
title_full The Hedgehog Signaling Pathway in Ischemic Tissues
title_fullStr The Hedgehog Signaling Pathway in Ischemic Tissues
title_full_unstemmed The Hedgehog Signaling Pathway in Ischemic Tissues
title_short The Hedgehog Signaling Pathway in Ischemic Tissues
title_sort hedgehog signaling pathway in ischemic tissues
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6862352/
https://www.ncbi.nlm.nih.gov/pubmed/31652910
http://dx.doi.org/10.3390/ijms20215270
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