Cargando…
Onychomycosis Unresponsive to Antifungals: Etiology and Treatment with a New Direct Technique
AIMS AND OBJECTIVES: The aim of this study was to identify the fungal agents causing onychomycosis that were unresponsive to antifungal treatment and to treat these cases by placing under-nail cushions with a mild keratolytic to clear the fungus-invaded tissue. MATERIALS AND METHODS: Fungal agents w...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer - Medknow
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6862374/ https://www.ncbi.nlm.nih.gov/pubmed/31896847 http://dx.doi.org/10.4103/ijd.IJD_453_18 |
_version_ | 1783471538211651584 |
---|---|
author | Erdogan, Fatma Gülru Yıldırım, Dilsun Çakır Akay, Gül Aslıhan |
author_facet | Erdogan, Fatma Gülru Yıldırım, Dilsun Çakır Akay, Gül Aslıhan |
author_sort | Erdogan, Fatma Gülru |
collection | PubMed |
description | AIMS AND OBJECTIVES: The aim of this study was to identify the fungal agents causing onychomycosis that were unresponsive to antifungal treatment and to treat these cases by placing under-nail cushions with a mild keratolytic to clear the fungus-invaded tissue. MATERIALS AND METHODS: Fungal agents were identified by the matrix-assisted laser desorption/ionization time of flight (MALDI-TOF) technique. RESULTS: Nine patients had Aspergillus spp. (7 Aspergillus niger, 2 Aspergillus flavus); four had Candida species and one had Trichophyton rubrum. All patients were free of infection at the end of treatment. CONCLUSION: As per the results, we may state that onychomycosis that is unresponsive to treatment in immunocompetent patients seems to be mostly associated with molds. Direct application of a mild keratolytic to the fungus-invaded part, e.g., the nail plate and/or nail bed and removal of fungal elements may provide a successful treatment outcome. |
format | Online Article Text |
id | pubmed-6862374 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-68623742020-01-02 Onychomycosis Unresponsive to Antifungals: Etiology and Treatment with a New Direct Technique Erdogan, Fatma Gülru Yıldırım, Dilsun Çakır Akay, Gül Aslıhan Indian J Dermatol Original Article AIMS AND OBJECTIVES: The aim of this study was to identify the fungal agents causing onychomycosis that were unresponsive to antifungal treatment and to treat these cases by placing under-nail cushions with a mild keratolytic to clear the fungus-invaded tissue. MATERIALS AND METHODS: Fungal agents were identified by the matrix-assisted laser desorption/ionization time of flight (MALDI-TOF) technique. RESULTS: Nine patients had Aspergillus spp. (7 Aspergillus niger, 2 Aspergillus flavus); four had Candida species and one had Trichophyton rubrum. All patients were free of infection at the end of treatment. CONCLUSION: As per the results, we may state that onychomycosis that is unresponsive to treatment in immunocompetent patients seems to be mostly associated with molds. Direct application of a mild keratolytic to the fungus-invaded part, e.g., the nail plate and/or nail bed and removal of fungal elements may provide a successful treatment outcome. Wolters Kluwer - Medknow 2019 /pmc/articles/PMC6862374/ /pubmed/31896847 http://dx.doi.org/10.4103/ijd.IJD_453_18 Text en Copyright: © 2019 Indian Journal of Dermatology http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Erdogan, Fatma Gülru Yıldırım, Dilsun Çakır Akay, Gül Aslıhan Onychomycosis Unresponsive to Antifungals: Etiology and Treatment with a New Direct Technique |
title | Onychomycosis Unresponsive to Antifungals: Etiology and Treatment with a New Direct Technique |
title_full | Onychomycosis Unresponsive to Antifungals: Etiology and Treatment with a New Direct Technique |
title_fullStr | Onychomycosis Unresponsive to Antifungals: Etiology and Treatment with a New Direct Technique |
title_full_unstemmed | Onychomycosis Unresponsive to Antifungals: Etiology and Treatment with a New Direct Technique |
title_short | Onychomycosis Unresponsive to Antifungals: Etiology and Treatment with a New Direct Technique |
title_sort | onychomycosis unresponsive to antifungals: etiology and treatment with a new direct technique |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6862374/ https://www.ncbi.nlm.nih.gov/pubmed/31896847 http://dx.doi.org/10.4103/ijd.IJD_453_18 |
work_keys_str_mv | AT erdoganfatmagulru onychomycosisunresponsivetoantifungalsetiologyandtreatmentwithanewdirecttechnique AT yıldırımdilsun onychomycosisunresponsivetoantifungalsetiologyandtreatmentwithanewdirecttechnique AT cakırakaygulaslıhan onychomycosisunresponsivetoantifungalsetiologyandtreatmentwithanewdirecttechnique |