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Expression of A New Endogenous Retrovirus-Associated Transcript in Hodgkin Lymphoma Cells
During characterization of a cDNA library from the Hodgkin lymphoma (HL) cell line L-1236, we discovered a new transcript derived from chromosome 1 at the long intergenic non-protein coding RNA 1768 (LINC01768)/colony stimulating factor 1 (CSF1) region. The first exon of this transcript from Hodgkin...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6862598/ https://www.ncbi.nlm.nih.gov/pubmed/31731509 http://dx.doi.org/10.3390/ijms20215320 |
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author | Schneider, Jana Volkmer, Ines Engel, Kristina Emmer, Alexander Staege, Martin S. |
author_facet | Schneider, Jana Volkmer, Ines Engel, Kristina Emmer, Alexander Staege, Martin S. |
author_sort | Schneider, Jana |
collection | PubMed |
description | During characterization of a cDNA library from the Hodgkin lymphoma (HL) cell line L-1236, we discovered a new transcript derived from chromosome 1 at the long intergenic non-protein coding RNA 1768 (LINC01768)/colony stimulating factor 1 (CSF1) region. The first exon of this transcript from Hodgkin lymphoma cells (THOLE) starts in the predicted exon 4 of LINC01768 and is part of an endogenous retrovirus (ERV) from the HUERS-P1/LTR8 family. High expression of THOLE was only detectable in HL cell line L-1236. The expression of THOLE in L-1236 cell is another example for ERV/LTR-associated gene expression in HL cells. At the genome level, the HUERS-P1/LTR8 region including THOLE is only present in Hominoidea. The influence of ERV/LTRs on gene expression might explain the characteristic phenotype of human HL. |
format | Online Article Text |
id | pubmed-6862598 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-68625982019-12-05 Expression of A New Endogenous Retrovirus-Associated Transcript in Hodgkin Lymphoma Cells Schneider, Jana Volkmer, Ines Engel, Kristina Emmer, Alexander Staege, Martin S. Int J Mol Sci Article During characterization of a cDNA library from the Hodgkin lymphoma (HL) cell line L-1236, we discovered a new transcript derived from chromosome 1 at the long intergenic non-protein coding RNA 1768 (LINC01768)/colony stimulating factor 1 (CSF1) region. The first exon of this transcript from Hodgkin lymphoma cells (THOLE) starts in the predicted exon 4 of LINC01768 and is part of an endogenous retrovirus (ERV) from the HUERS-P1/LTR8 family. High expression of THOLE was only detectable in HL cell line L-1236. The expression of THOLE in L-1236 cell is another example for ERV/LTR-associated gene expression in HL cells. At the genome level, the HUERS-P1/LTR8 region including THOLE is only present in Hominoidea. The influence of ERV/LTRs on gene expression might explain the characteristic phenotype of human HL. MDPI 2019-10-25 /pmc/articles/PMC6862598/ /pubmed/31731509 http://dx.doi.org/10.3390/ijms20215320 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Schneider, Jana Volkmer, Ines Engel, Kristina Emmer, Alexander Staege, Martin S. Expression of A New Endogenous Retrovirus-Associated Transcript in Hodgkin Lymphoma Cells |
title | Expression of A New Endogenous Retrovirus-Associated Transcript in Hodgkin Lymphoma Cells |
title_full | Expression of A New Endogenous Retrovirus-Associated Transcript in Hodgkin Lymphoma Cells |
title_fullStr | Expression of A New Endogenous Retrovirus-Associated Transcript in Hodgkin Lymphoma Cells |
title_full_unstemmed | Expression of A New Endogenous Retrovirus-Associated Transcript in Hodgkin Lymphoma Cells |
title_short | Expression of A New Endogenous Retrovirus-Associated Transcript in Hodgkin Lymphoma Cells |
title_sort | expression of a new endogenous retrovirus-associated transcript in hodgkin lymphoma cells |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6862598/ https://www.ncbi.nlm.nih.gov/pubmed/31731509 http://dx.doi.org/10.3390/ijms20215320 |
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