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Expression of A New Endogenous Retrovirus-Associated Transcript in Hodgkin Lymphoma Cells

During characterization of a cDNA library from the Hodgkin lymphoma (HL) cell line L-1236, we discovered a new transcript derived from chromosome 1 at the long intergenic non-protein coding RNA 1768 (LINC01768)/colony stimulating factor 1 (CSF1) region. The first exon of this transcript from Hodgkin...

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Autores principales: Schneider, Jana, Volkmer, Ines, Engel, Kristina, Emmer, Alexander, Staege, Martin S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6862598/
https://www.ncbi.nlm.nih.gov/pubmed/31731509
http://dx.doi.org/10.3390/ijms20215320
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author Schneider, Jana
Volkmer, Ines
Engel, Kristina
Emmer, Alexander
Staege, Martin S.
author_facet Schneider, Jana
Volkmer, Ines
Engel, Kristina
Emmer, Alexander
Staege, Martin S.
author_sort Schneider, Jana
collection PubMed
description During characterization of a cDNA library from the Hodgkin lymphoma (HL) cell line L-1236, we discovered a new transcript derived from chromosome 1 at the long intergenic non-protein coding RNA 1768 (LINC01768)/colony stimulating factor 1 (CSF1) region. The first exon of this transcript from Hodgkin lymphoma cells (THOLE) starts in the predicted exon 4 of LINC01768 and is part of an endogenous retrovirus (ERV) from the HUERS-P1/LTR8 family. High expression of THOLE was only detectable in HL cell line L-1236. The expression of THOLE in L-1236 cell is another example for ERV/LTR-associated gene expression in HL cells. At the genome level, the HUERS-P1/LTR8 region including THOLE is only present in Hominoidea. The influence of ERV/LTRs on gene expression might explain the characteristic phenotype of human HL.
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spelling pubmed-68625982019-12-05 Expression of A New Endogenous Retrovirus-Associated Transcript in Hodgkin Lymphoma Cells Schneider, Jana Volkmer, Ines Engel, Kristina Emmer, Alexander Staege, Martin S. Int J Mol Sci Article During characterization of a cDNA library from the Hodgkin lymphoma (HL) cell line L-1236, we discovered a new transcript derived from chromosome 1 at the long intergenic non-protein coding RNA 1768 (LINC01768)/colony stimulating factor 1 (CSF1) region. The first exon of this transcript from Hodgkin lymphoma cells (THOLE) starts in the predicted exon 4 of LINC01768 and is part of an endogenous retrovirus (ERV) from the HUERS-P1/LTR8 family. High expression of THOLE was only detectable in HL cell line L-1236. The expression of THOLE in L-1236 cell is another example for ERV/LTR-associated gene expression in HL cells. At the genome level, the HUERS-P1/LTR8 region including THOLE is only present in Hominoidea. The influence of ERV/LTRs on gene expression might explain the characteristic phenotype of human HL. MDPI 2019-10-25 /pmc/articles/PMC6862598/ /pubmed/31731509 http://dx.doi.org/10.3390/ijms20215320 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Schneider, Jana
Volkmer, Ines
Engel, Kristina
Emmer, Alexander
Staege, Martin S.
Expression of A New Endogenous Retrovirus-Associated Transcript in Hodgkin Lymphoma Cells
title Expression of A New Endogenous Retrovirus-Associated Transcript in Hodgkin Lymphoma Cells
title_full Expression of A New Endogenous Retrovirus-Associated Transcript in Hodgkin Lymphoma Cells
title_fullStr Expression of A New Endogenous Retrovirus-Associated Transcript in Hodgkin Lymphoma Cells
title_full_unstemmed Expression of A New Endogenous Retrovirus-Associated Transcript in Hodgkin Lymphoma Cells
title_short Expression of A New Endogenous Retrovirus-Associated Transcript in Hodgkin Lymphoma Cells
title_sort expression of a new endogenous retrovirus-associated transcript in hodgkin lymphoma cells
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6862598/
https://www.ncbi.nlm.nih.gov/pubmed/31731509
http://dx.doi.org/10.3390/ijms20215320
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