Invariant NKT Cells and Rheumatic Disease: Focus on Primary Sjogren Syndrome

Primary Sjogren syndrome (pSS) is a complex autoimmune disease mainly affecting salivary and lacrimal glands. Several factors contribute to pSS pathogenesis; in particular, innate immunity seems to play a key role in disease etiology. Invariant natural killer (NK) T cells (iNKT) are a T-cell subset...

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Autores principales: Rizzo, Chiara, La Barbera, Lidia, Lo Pizzo, Marianna, Ciccia, Francesco, Sireci, Guido, Guggino, Giuliana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6862604/
https://www.ncbi.nlm.nih.gov/pubmed/31683641
http://dx.doi.org/10.3390/ijms20215435
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author Rizzo, Chiara
La Barbera, Lidia
Lo Pizzo, Marianna
Ciccia, Francesco
Sireci, Guido
Guggino, Giuliana
author_facet Rizzo, Chiara
La Barbera, Lidia
Lo Pizzo, Marianna
Ciccia, Francesco
Sireci, Guido
Guggino, Giuliana
author_sort Rizzo, Chiara
collection PubMed
description Primary Sjogren syndrome (pSS) is a complex autoimmune disease mainly affecting salivary and lacrimal glands. Several factors contribute to pSS pathogenesis; in particular, innate immunity seems to play a key role in disease etiology. Invariant natural killer (NK) T cells (iNKT) are a T-cell subset able to recognize glycolipid antigens. Their function remains unclear, but studies have pointed out their ability to modulate the immune system through the promotion of specific cytokine milieu. In this review, we discussed the possible role of iNKT in pSS development, as well as their implications as future markers of disease activity.
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spelling pubmed-68626042019-12-05 Invariant NKT Cells and Rheumatic Disease: Focus on Primary Sjogren Syndrome Rizzo, Chiara La Barbera, Lidia Lo Pizzo, Marianna Ciccia, Francesco Sireci, Guido Guggino, Giuliana Int J Mol Sci Review Primary Sjogren syndrome (pSS) is a complex autoimmune disease mainly affecting salivary and lacrimal glands. Several factors contribute to pSS pathogenesis; in particular, innate immunity seems to play a key role in disease etiology. Invariant natural killer (NK) T cells (iNKT) are a T-cell subset able to recognize glycolipid antigens. Their function remains unclear, but studies have pointed out their ability to modulate the immune system through the promotion of specific cytokine milieu. In this review, we discussed the possible role of iNKT in pSS development, as well as their implications as future markers of disease activity. MDPI 2019-10-31 /pmc/articles/PMC6862604/ /pubmed/31683641 http://dx.doi.org/10.3390/ijms20215435 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Rizzo, Chiara
La Barbera, Lidia
Lo Pizzo, Marianna
Ciccia, Francesco
Sireci, Guido
Guggino, Giuliana
Invariant NKT Cells and Rheumatic Disease: Focus on Primary Sjogren Syndrome
title Invariant NKT Cells and Rheumatic Disease: Focus on Primary Sjogren Syndrome
title_full Invariant NKT Cells and Rheumatic Disease: Focus on Primary Sjogren Syndrome
title_fullStr Invariant NKT Cells and Rheumatic Disease: Focus on Primary Sjogren Syndrome
title_full_unstemmed Invariant NKT Cells and Rheumatic Disease: Focus on Primary Sjogren Syndrome
title_short Invariant NKT Cells and Rheumatic Disease: Focus on Primary Sjogren Syndrome
title_sort invariant nkt cells and rheumatic disease: focus on primary sjogren syndrome
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6862604/
https://www.ncbi.nlm.nih.gov/pubmed/31683641
http://dx.doi.org/10.3390/ijms20215435
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