TPP-related mitochondrial targeting copper (II) complex induces p53-dependent apoptosis in hepatoma cells through ROS-mediated activation of Drp1

BACKGROUND: In recent years, copper complexes have gradually become the focus of potential anticancer drugs due to their available redox properties and low toxicity. In this study, a novel mitochondrion-targeting copper (II) complex, [Cu (ttpy-tpp)Br(2)] Br (simplified as CTB), is first synthesized...

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Detalles Bibliográficos
Autores principales: Shao, Jiangjuan, Li, Mengmeng, Guo, Zijian, Jin, Chun, Zhang, Feng, Ou, Chunyan, Xie, Yaochen, Tan, Shanzhong, Wang, Zhenyi, Zheng, Shizhong, Wang, Xiaoyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6862763/
https://www.ncbi.nlm.nih.gov/pubmed/31744518
http://dx.doi.org/10.1186/s12964-019-0468-6

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