Wild-type Cu/Zn-superoxide dismutase is misfolded in cerebrospinal fluid of sporadic amyotrophic lateral sclerosis

BACKGROUND: A subset of familial forms of amyotrophic lateral sclerosis (ALS) are caused by mutations in the gene coding Cu/Zn-superoxide dismutase (SOD1). Mutant SOD1 proteins are susceptible to misfolding and abnormally accumulated in spinal cord, which is most severely affected in ALS. It, howeve...

Descripción completa

Detalles Bibliográficos
Autores principales: Tokuda, Eiichi, Takei, Yo-ichi, Ohara, Shinji, Fujiwara, Noriko, Hozumi, Isao, Furukawa, Yoshiaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6862823/
https://www.ncbi.nlm.nih.gov/pubmed/31744522
http://dx.doi.org/10.1186/s13024-019-0341-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6862823/
https://www.ncbi.nlm.nih.gov/pubmed/31744522
http://dx.doi.org/10.1186/s13024-019-0341-5

Ejemplares similares