Neuronal maturation reduces the type I IFN response to orthobunyavirus infection and leads to increased apoptosis of human neurons

BACKGROUND: La Crosse virus (LACV) is the leading cause of pediatric arboviral encephalitis in the USA. LACV encephalitis can result in learning and memory deficits, which may be due to infection and apoptosis of neurons in the brain. Despite neurons being the primary cell infected in the brain by L...

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Detalles Bibliográficos
Autores principales: Winkler, Clayton W., Woods, Tyson A., Groveman, Bradley R., Carmody, Aaron B., Speranza, Emily E., Martens, Craig A., Best, Sonja M., Haigh, Cathryn L., Peterson, Karin E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6862864/
https://www.ncbi.nlm.nih.gov/pubmed/31739796
http://dx.doi.org/10.1186/s12974-019-1614-1

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