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Role of Microparticles in the Pathogenesis of Inflammatory Joint Diseases

Rheumatoid arthritis (RA), juvenile idiopathic arthritis (JIA), ankylosing spondylitis (AS), and psoriatic arthritis (PsA) make up a group of chronic immune-mediated inflammatory diseases (IMIDs). The course of these diseases involves chronic inflammation of joints and enthesopathies, which can resu...

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Autores principales: Krajewska-Włodarczyk, Magdalena, Owczarczyk-Saczonek, Agnieszka, Żuber, Zbigniew, Wojtkiewicz, Maja, Wojtkiewicz, Joanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6862866/
https://www.ncbi.nlm.nih.gov/pubmed/31683793
http://dx.doi.org/10.3390/ijms20215453
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author Krajewska-Włodarczyk, Magdalena
Owczarczyk-Saczonek, Agnieszka
Żuber, Zbigniew
Wojtkiewicz, Maja
Wojtkiewicz, Joanna
author_facet Krajewska-Włodarczyk, Magdalena
Owczarczyk-Saczonek, Agnieszka
Żuber, Zbigniew
Wojtkiewicz, Maja
Wojtkiewicz, Joanna
author_sort Krajewska-Włodarczyk, Magdalena
collection PubMed
description Rheumatoid arthritis (RA), juvenile idiopathic arthritis (JIA), ankylosing spondylitis (AS), and psoriatic arthritis (PsA) make up a group of chronic immune-mediated inflammatory diseases (IMIDs). The course of these diseases involves chronic inflammation of joints and enthesopathies, which can result in joint damage and disability. Microparticles (MPs) are a group of small spherical membranous vesicles. The structure and cellular origin of MPs, mechanisms that stimulate their secretion and the place of their production, determine their biological properties, which could become manifest in the pathogenesis of immune-mediated inflammatory diseases. Microparticles can stimulate synovitis with proinflammatory cytokines and chemokines. MPs may also contribute to the pathogenesis of rheumatic diseases by the formation of immune complexes and complement activation, pro-coagulation activity, activation of vascular endothelium cells, and stimulation of metalloproteinase production. It seems that in the future, microparticles can become a modern marker of disease activity, a response to treatment, and, possibly, they can be used in the prognosis of the course of arthritis. The knowledge of the complexity of MPs biology remains incomplete and it requires further comprehensive studies to explain how they affect the development of rheumatic diseases. This review focuses on the immunopathogenic and therapeutic role of MPs in chronic immune-mediated inflammatory joint diseases.
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spelling pubmed-68628662019-12-23 Role of Microparticles in the Pathogenesis of Inflammatory Joint Diseases Krajewska-Włodarczyk, Magdalena Owczarczyk-Saczonek, Agnieszka Żuber, Zbigniew Wojtkiewicz, Maja Wojtkiewicz, Joanna Int J Mol Sci Review Rheumatoid arthritis (RA), juvenile idiopathic arthritis (JIA), ankylosing spondylitis (AS), and psoriatic arthritis (PsA) make up a group of chronic immune-mediated inflammatory diseases (IMIDs). The course of these diseases involves chronic inflammation of joints and enthesopathies, which can result in joint damage and disability. Microparticles (MPs) are a group of small spherical membranous vesicles. The structure and cellular origin of MPs, mechanisms that stimulate their secretion and the place of their production, determine their biological properties, which could become manifest in the pathogenesis of immune-mediated inflammatory diseases. Microparticles can stimulate synovitis with proinflammatory cytokines and chemokines. MPs may also contribute to the pathogenesis of rheumatic diseases by the formation of immune complexes and complement activation, pro-coagulation activity, activation of vascular endothelium cells, and stimulation of metalloproteinase production. It seems that in the future, microparticles can become a modern marker of disease activity, a response to treatment, and, possibly, they can be used in the prognosis of the course of arthritis. The knowledge of the complexity of MPs biology remains incomplete and it requires further comprehensive studies to explain how they affect the development of rheumatic diseases. This review focuses on the immunopathogenic and therapeutic role of MPs in chronic immune-mediated inflammatory joint diseases. MDPI 2019-11-01 /pmc/articles/PMC6862866/ /pubmed/31683793 http://dx.doi.org/10.3390/ijms20215453 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Krajewska-Włodarczyk, Magdalena
Owczarczyk-Saczonek, Agnieszka
Żuber, Zbigniew
Wojtkiewicz, Maja
Wojtkiewicz, Joanna
Role of Microparticles in the Pathogenesis of Inflammatory Joint Diseases
title Role of Microparticles in the Pathogenesis of Inflammatory Joint Diseases
title_full Role of Microparticles in the Pathogenesis of Inflammatory Joint Diseases
title_fullStr Role of Microparticles in the Pathogenesis of Inflammatory Joint Diseases
title_full_unstemmed Role of Microparticles in the Pathogenesis of Inflammatory Joint Diseases
title_short Role of Microparticles in the Pathogenesis of Inflammatory Joint Diseases
title_sort role of microparticles in the pathogenesis of inflammatory joint diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6862866/
https://www.ncbi.nlm.nih.gov/pubmed/31683793
http://dx.doi.org/10.3390/ijms20215453
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