Antimicrobial-resistant Gram-negative colonization in infants from a neonatal intensive care unit in Thailand

Antimicrobial-resistant Gram-negative bacteria are a major cause of morbidity and mortality in hospitalized neonates in South and South-East Asia. This study aimed to determine the dynamics of colonization with antimicrobial-resistant Gram-negative bacteria amongst patients in a neonatal intensive c...

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Detalles Bibliográficos
Autores principales: Roberts, T., Limmathurotsakul, D., Turner, P., Day, N.P.J., Vandepitte, W.P., Cooper, B.S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: W.B. Saunders For The Hospital Infection Society 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6863035/
https://www.ncbi.nlm.nih.gov/pubmed/30995491
http://dx.doi.org/10.1016/j.jhin.2019.04.004
Descripción
Sumario:Antimicrobial-resistant Gram-negative bacteria are a major cause of morbidity and mortality in hospitalized neonates in South and South-East Asia. This study aimed to determine the dynamics of colonization with antimicrobial-resistant Gram-negative bacteria amongst patients in a neonatal intensive care unit (NICU) in Thailand. From 97 enrolled patients, 52% were colonized by an extended-spectrum β-lactamase (ESBL) organism at some point during their stay and 64% were colonized by a carbapenem-resistant organism. Rapid acquisition of ESBL-positive and carbapenem-resistant organisms was found. Once colonized with an antibiotic-resistant organism, patients remained colonized for the remainder of their NICU stay.

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