Sporadic Early-Onset Diffuse Gastric Cancers Have High Frequency of Somatic CDH1 Alterations, but Low Frequency of Somatic RHOA Mutations Compared With Late-Onset Cancers

BACKGROUND & AIMS: Early-onset gastric cancer, which develops in patients younger than most gastric cancers, is usually detected at advanced stages, has diffuse histologic features, and occurs more frequently in women. We investigated somatic genomic alterations associated with the unique charac...

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Detalles Bibliográficos
Autores principales: Cho, Soo Young, Park, Jun Won, Liu, Yang, Park, Young Soo, Kim, Ju Hee, Yang, Hanna, Um, Hyejin, Ko, Woo Ri, Lee, Byung Il, Kwon, Sun Young, Ryu, Seung Wan, Kwon, Chae Hwa, Park, Do Youn, Lee, Jae-Hyuk, Lee, Sang Il, Song, Kyu Sang, Hur, Hoon, Han, Sang-Uk, Chang, Heekyung, Kim, Su-Jin, Kim, Byung-Sik, Yook, Jeong-Hwan, Yoo, Moon-Won, Kim, Beom-Su, Lee, In-Seob, Kook, Myeong-Cherl, Thiessen, Nina, He, An, Stewart, Chip, Dunford, Andrew, Kim, Jaegil, Shih, Juliann, Saksena, Gordon, Cherniack, Andrew D., Schumacher, Steven, Weiner, Amaro-Taylor, Rosenberg, Mara, Getz, Gad, Yang, Eun Gyeong, Ryu, Min-Hee, Bass, Adam J., Kim, Hark Kyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6863080/
https://www.ncbi.nlm.nih.gov/pubmed/28522256
http://dx.doi.org/10.1053/j.gastro.2017.05.012

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