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Sub-Foveal Choroidal Thickness In Healthy Nepalese Population

PURPOSE: This study was conducted primarily to measure sub-foveal choroidal thickness (SFCT) in healthy Nepalese population. Also, the correlation of SFCT with age, inter-eye difference of SFCT, inter-gender variation and inter-ethnic variation of SFCT was observed. MATERIALS AND METHODS: A cross-se...

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Autores principales: Gyawali, Parash, Kharel Sitaula, Ranju, Kharal, Anish, Bhusal, Asmita, Paudel, Manisha, Joshi, Sagun Narayan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6863127/
https://www.ncbi.nlm.nih.gov/pubmed/31814789
http://dx.doi.org/10.2147/OPTO.S220615
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author Gyawali, Parash
Kharel Sitaula, Ranju
Kharal, Anish
Bhusal, Asmita
Paudel, Manisha
Joshi, Sagun Narayan
author_facet Gyawali, Parash
Kharel Sitaula, Ranju
Kharal, Anish
Bhusal, Asmita
Paudel, Manisha
Joshi, Sagun Narayan
author_sort Gyawali, Parash
collection PubMed
description PURPOSE: This study was conducted primarily to measure sub-foveal choroidal thickness (SFCT) in healthy Nepalese population. Also, the correlation of SFCT with age, inter-eye difference of SFCT, inter-gender variation and inter-ethnic variation of SFCT was observed. MATERIALS AND METHODS: A cross-sectional, hospital based study in 162 participants (324 eyes) of six ethnic groups (Brahmin, Chhetri, Newar, Tamang, Muslim, and Gurung) was conducted. The mean age of participants was 37.37 ± 15.02 years. All the participants underwent SFCT measurement using Spectral Domain Optical Coherence Tomography (Spectralis HRA+OCT, Heidelberg Engineering, Germany) with the help of in-built caliber. Age, inter-gender, inter-eye and inter-ethnic differences in SFCT were recorded and analyzed. RESULTS: The average SFCT of right eye (RE) and left eye (LE) was 307.98 ± 74.64 µm and 312.63 ± 76.90 µm respectively, with average SFCT of 310.31 ± 75.70 µm for both eyes. SFCT of only the RE was selected for further calculation due to insignificant inter-eye difference of SFCT (p = 0.128). There was a significant negative correlation of SFCT with age (r = −0.705, p = 0.01). A regression analysis showed thinning of SFCT by 3.50 ± 0.278 µm per year. In another context, SFCT of male and female was 305.49 ± 79.72 µm and 313.55 ± 70.76 µm respectively. However, there was no significant inter-gender difference (p = 0.51). Similarly, inter-ethnic variations of SFCT was also statistically non -significant (p = 0.74). CONCLUSION: SFCT was negatively correlated with the age of participants, implying a decrease in choroidal thickness (CT) with an increase in age. Age can be considered as an important factor in the measurement of SFCT. Gender and ethnic groups did not have a significant role in the measurement and comparison of SFCT.
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spelling pubmed-68631272019-12-06 Sub-Foveal Choroidal Thickness In Healthy Nepalese Population Gyawali, Parash Kharel Sitaula, Ranju Kharal, Anish Bhusal, Asmita Paudel, Manisha Joshi, Sagun Narayan Clin Optom (Auckl) Original Research PURPOSE: This study was conducted primarily to measure sub-foveal choroidal thickness (SFCT) in healthy Nepalese population. Also, the correlation of SFCT with age, inter-eye difference of SFCT, inter-gender variation and inter-ethnic variation of SFCT was observed. MATERIALS AND METHODS: A cross-sectional, hospital based study in 162 participants (324 eyes) of six ethnic groups (Brahmin, Chhetri, Newar, Tamang, Muslim, and Gurung) was conducted. The mean age of participants was 37.37 ± 15.02 years. All the participants underwent SFCT measurement using Spectral Domain Optical Coherence Tomography (Spectralis HRA+OCT, Heidelberg Engineering, Germany) with the help of in-built caliber. Age, inter-gender, inter-eye and inter-ethnic differences in SFCT were recorded and analyzed. RESULTS: The average SFCT of right eye (RE) and left eye (LE) was 307.98 ± 74.64 µm and 312.63 ± 76.90 µm respectively, with average SFCT of 310.31 ± 75.70 µm for both eyes. SFCT of only the RE was selected for further calculation due to insignificant inter-eye difference of SFCT (p = 0.128). There was a significant negative correlation of SFCT with age (r = −0.705, p = 0.01). A regression analysis showed thinning of SFCT by 3.50 ± 0.278 µm per year. In another context, SFCT of male and female was 305.49 ± 79.72 µm and 313.55 ± 70.76 µm respectively. However, there was no significant inter-gender difference (p = 0.51). Similarly, inter-ethnic variations of SFCT was also statistically non -significant (p = 0.74). CONCLUSION: SFCT was negatively correlated with the age of participants, implying a decrease in choroidal thickness (CT) with an increase in age. Age can be considered as an important factor in the measurement of SFCT. Gender and ethnic groups did not have a significant role in the measurement and comparison of SFCT. Dove 2019-11-15 /pmc/articles/PMC6863127/ /pubmed/31814789 http://dx.doi.org/10.2147/OPTO.S220615 Text en © 2019 Gyawali et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Gyawali, Parash
Kharel Sitaula, Ranju
Kharal, Anish
Bhusal, Asmita
Paudel, Manisha
Joshi, Sagun Narayan
Sub-Foveal Choroidal Thickness In Healthy Nepalese Population
title Sub-Foveal Choroidal Thickness In Healthy Nepalese Population
title_full Sub-Foveal Choroidal Thickness In Healthy Nepalese Population
title_fullStr Sub-Foveal Choroidal Thickness In Healthy Nepalese Population
title_full_unstemmed Sub-Foveal Choroidal Thickness In Healthy Nepalese Population
title_short Sub-Foveal Choroidal Thickness In Healthy Nepalese Population
title_sort sub-foveal choroidal thickness in healthy nepalese population
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6863127/
https://www.ncbi.nlm.nih.gov/pubmed/31814789
http://dx.doi.org/10.2147/OPTO.S220615
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