Cargando…

Oncogenic Activities Of UBE2S Mediated By VHL/HIF-1α/STAT3 Signal Via The Ubiquitin-Proteasome System In PDAC

PURPOSE: Ubiquitin-conjugating enzyme E2S (UBE2S) is important for the development and progression of several types of cancer. However, neither the role of UBE2S in pancreatic cancer nor its mechanism is clear. METHODS: We analyzed three GEO datasets to obtain 150 differentially expressed genes (DEG...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Lei, Liang, Yiyi, Li, Pengping, Liang, Qingchun, Sun, Haijun, Xu, Dazhou, Hu, Wei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2019
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6863183/ https://www.ncbi.nlm.nih.gov/pubmed/31814735 http://dx.doi.org/10.2147/OTT.S228522

Ejemplares similares

UBE2S promotes malignant properties via VHL/HIF‐1α and VHL/JAK2/STAT3 signaling pathways and decreases sensitivity to sorafenib in hepatocellular carcinoma
por: Wu, Junyi, et al.
Publicado: (2023)

Beluga whale pVHL enhances HIF-2α activity via inducing HIF-2α proteasomal degradation under hypoxia
por: Bi, Jianling, et al.
Publicado: (2017)

Newcastle disease virus degrades HIF-1α through proteasomal pathways independent of VHL and p53
por: Abd-Aziz, Noraini, et al.
Publicado: (2016)

Conjugation of the Ubiquitin Activating Enzyme UBE1 with the Ubiquitin-Like Modifier FAT10 Targets It for Proteasomal Degradation
por: Bialas, Johanna, et al.
Publicado: (2015)

TARBP2 Suppresses Ubiquitin-Proteasomal Degradation of HIF-1α in Breast Cancer
por: Li, Jie-Ning, et al.
Publicado: (2021)

Playing Tag with HIF: The VHL Story
por: Leung, Sherri K., et al.
Publicado: (2002)

VHL-P138R and VHL-L163R Novel Variants: Mechanisms of VHL Pathogenicity Involving HIF-Dependent and HIF-Independent Actions
por: Mathó, Cecilia, et al.
Publicado: (2022)

Tetrahydrobiopterin modulates ubiquitin conjugation to UBC13/UBE2N and proteasome activity by S-nitrosation
por: Bailey, Jade, et al.
Publicado: (2018)

CypA, a Gene Downstream of HIF-1α, Promotes the Development of PDAC
por: Zhang, Huan, et al.
Publicado: (2014)

Targeting the von Hippel–Lindau E3 Ubiquitin Ligase Using Small Molecules To Disrupt the VHL/HIF-1α Interaction
por: Buckley, Dennis L., et al.
Publicado: (2012)

Transmembrane Protein 100 Inhibits the Progression of Colorectal Cancer by Promoting the Ubiquitin/Proteasome Degradation of HIF-1α
por: Zheng, Ying, et al.
Publicado: (2022)

Pharmacological Modulation of Ubiquitin-Proteasome Pathways in Oncogenic Signaling
por: Sharma, Anmol, et al.
Publicado: (2021)

VHL and Hypoxia Signaling: Beyond HIF in Cancer
por: Zhang, Jing, et al.
Publicado: (2018)

HIF-2α-pVHL complex reveals broad genotype-phenotype correlations in HIF-2α-driven disease
por: Tarade, Daniel, et al.
Publicado: (2018)

Evolution of metazoan oxygen-sensing involved a conserved divergence of VHL affinity for HIF1α and HIF2α
por: Tarade, Daniel, et al.
Publicado: (2019)

Vhl deletion in renal epithelia causes HIF-1α-dependent, HIF-2α-independent angiogenesis and constitutive diuresis
por: Schönenberger, Désirée, et al.
Publicado: (2016)

HIF-2α downregulation in the absence of functional VHL is not sufficient for renal cell differentiation
por: Hughes, Michael D, et al.
Publicado: (2007)

Inhibition of HIF2α Is Sufficient to Suppress pVHL-Defective Tumor Growth
por: Kondo, Keiichi, et al.
Publicado: (2003)

Inhibition of HIF2α Protein Suppresses pVHL-Driven Tumor Growth
Publicado: (2003)

Oxygen-independent degradation of HIF-α via bioengineered VHL tumour suppressor complex
por: Sufan, Roxana I, et al.
Publicado: (2009)

Phospholipase D1 protein coordinates dynamic assembly of HIF-1α-PHD-VHL to regulate HIF-1α stability
por: Park, Mi Hee, et al.
Publicado: (2014)

HIF2a inhibitors for the treatment of VHL disease
por: Metelo, Ana Martins, et al.
Publicado: (2015)

The VHL/HIF Axis in the Development and Treatment of Pheochromocytoma/Paraganglioma
por: Peng, Song, et al.
Publicado: (2020)

The Roles of VHL-Dependent Ubiquitination in Signaling and Cancer
por: Zhang, Qing, et al.
Publicado: (2012)

Human Papillomavirus 16 E6 Contributes HIF-1α Induced Warburg Effect by Attenuating the VHL-HIF-1α Interaction
por: Guo, Yi, et al.
Publicado: (2014)

Histone deacetylase inhibitor induced pVHL-independent degradation of HIF-1α and hierarchical quality control of pVHL via chaperone system
por: Ni, Jieming, et al.
Publicado: (2021)

Renal Tubular HIF-2α Expression Requires VHL Inactivation and Causes Fibrosis and Cysts
por: Schietke, Ruth E., et al.
Publicado: (2012)

Astrocyte pVHL and HIF-α isoforms are required for embryonic-to-adult vascular transition in the eye
por: Kurihara, Toshihide, et al.
Publicado: (2011)

Septin4 promotes cardiomyocytes apoptosis by enhancing the VHL-mediated degradation of HIF-1α
por: Wu, Shaojun, et al.
Publicado: (2021)

HIV-1 Impairment via UBE3A and HIV-1 Nef Interactions Utilizing the Ubiquitin Proteasome System
por: Pyeon, Dohun, et al.
Publicado: (2019)

Two sides to every story: the HIF-dependent and HIF-independent functions of pVHL
por: Li, Mingqing, et al.
Publicado: (2011)

RNF4 and VHL regulate the proteasomal degradation of SUMO-conjugated Hypoxia-Inducible Factor-2α
por: van Hagen, Martijn, et al.
Publicado: (2010)

Foxp3 enhances HIF-1α target gene expression in human bladder cancer through decreasing its ubiquitin-proteasomal degradation
por: Jou, Yeong-Chin, et al.
Publicado: (2016)

Targeting HIF2α Translation with Tempol in VHL-Deficient Clear Cell Renal Cell Carcinoma
por: Sourbier, Carole, et al.
Publicado: (2012)

Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition
por: Frost, Julianty, et al.
Publicado: (2016)

Angelman syndrome-associated ubiquitin ligase UBE3A/E6AP mutants interfere with the proteolytic activity of the proteasome
por: Tomaić, V, et al.
Publicado: (2015)

Ube2W conjugates ubiquitin to α-amino groups of protein N-termini
por: Tatham, Michael H., et al.
Publicado: (2013)

Anti-cancer efficacy including Rb-deficient tumors and VHL-independent HIF1α proteasomal destabilization by dual targeting of CDK1 or CDK4/6 and HSP90
por: Zhao, Shuai, et al.
Publicado: (2021)

Wogonin inhibits multiple myeloma-stimulated angiogenesis via c-Myc/VHL/HIF-1α signaling axis
por: Fu, Rong, et al.
Publicado: (2015)

Investigation of the role of VHL-HIF signaling in DNA repair and apoptosis in zebrafish
por: Kim, Hyejeong Rosemary, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_fk89v6n0ue1mrbr50hm75jki3j