Cargando…

Polyamines Control eIF5A Hypusination, TFEB Translation, and Autophagy to Reverse B Cell Senescence

Failure to make adaptive immune responses is a hallmark of aging. Reduced B cell function leads to poor vaccination efficacy and a high prevalence of infections in the elderly. Here we show that reduced autophagy is a central molecular mechanism underlying immune senescence. Autophagy levels are spe...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Hanlin, Alsaleh, Ghada, Feltham, Jack, Sun, Yizhe, Napolitano, Gennaro, Riffelmacher, Thomas, Charles, Philip, Frau, Lisa, Hublitz, Philip, Yu, Zhanru, Mohammed, Shabaz, Ballabio, Andrea, Balabanov, Stefan, Mellor, Jane, Simon, Anna Katharina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6863385/ https://www.ncbi.nlm.nih.gov/pubmed/31474573 http://dx.doi.org/10.1016/j.molcel.2019.08.005

Ejemplares similares

Polyamines and eIF5A Hypusination Modulate Mitochondrial Respiration and Macrophage Activation
por: Puleston, Daniel J., et al.
Publicado: (2019)

Amino acid substrates impose polyamine, eIF5A, or hypusine requirement for peptide synthesis
por: Shin, Byung-Sik, et al.
Publicado: (2017)

Polyamines and Hypusination Are Required for Ebolavirus Gene Expression and Replication
por: Olsen, Michelle E., et al.
Publicado: (2016)

Role of Polyamines and Hypusine in β Cells and Diabetes Pathogenesis
por: Kulkarni, Abhishek, et al.
Publicado: (2022)

Polyamine biosynthesis and eIF5A hypusination are modulated by the DNA tumor virus KSHV and promote KSHV viral infection
por: Fiches, Guillaume N., et al.
Publicado: (2022)

Polyamines and eIF5A hypusination facilitate SREBP2 synthesis and cholesterol production leading to enhanced enterovirus attachment and infection
por: Firpo, Mason R., et al.
Publicado: (2023)

YAP/TAZ drives cell proliferation and tumor growth via a polyamine-eIF5A hypusination-LSD1 axis
por: Li, Hongde, et al.
Publicado: (2022)

Hypusine-containing Protein eIF5A Promotes Translation Elongation
por: Saini, Preeti, et al.
Publicado: (2009)

Correction for Olsen et al., “Polyamines and Hypusination Are Required for Ebolavirus Gene Expression and Replication”
por: Olsen, Michelle E., et al.
Publicado: (2018)

Post-translational formation of hypusine in eIF5A: implications in human neurodevelopment
por: Park, Myung Hee, et al.
Publicado: (2021)

Modulating the polyamine/hypusine axis controls generation of CD8(+) tissue-resident memory T cells
por: Elmarsafawi, Aya G., et al.
Publicado: (2023)

Inhibition of eIF5A hypusination reprogrammes metabolism and glucose handling in mouse kidney
por: Cougnon, Marc, et al.
Publicado: (2021)

Ciclopirox Inhibition of eIF5A Hypusination Attenuates Fibroblast Activation and Cardiac Fibrosis
por: Subbaiah, Kadiam C. Venkata, et al.
Publicado: (2023)

Biochemical quantitation of the eIF5A hypusination in Arabidopsis thaliana uncovers ABA-dependent regulation
por: Belda-Palazón, Borja, et al.
Publicado: (2014)

Inhibition of eIF5A hypusination pathway as a new pharmacological target for stroke therapy
por: Bourourou, Miled, et al.
Publicado: (2020)

Blockade of EIF5A hypusination limits colorectal cancer growth by inhibiting MYC elongation
por: Coni, Sonia, et al.
Publicado: (2020)

mTOR-dependent phosphorylation controls TFEB nuclear export
por: Napolitano, Gennaro, et al.
Publicado: (2018)

Structure of the lysosomal mTORC1–TFEB–Rag–Ragulator megacomplex
por: Cui, Zhicheng, et al.
Publicado: (2023)

Hypusinated eIF5A is expressed in the pancreas and spleen of individuals with type 1 and type 2 diabetes
por: Mastracci, Teresa L., et al.
Publicado: (2020)

Protein-protein-interaction Network Organization of the Hypusine Modification System
por: Sievert, Henning, et al.
Publicado: (2012)

Structure of the exportin Xpo4 in complex with RanGTP and the hypusine-containing translation factor eIF5A
por: Aksu, Metin, et al.
Publicado: (2016)

Hypusination, a Metabolic Posttranslational Modification of eIF5A in Plants during Development and Environmental Stress Responses
por: Pálfi, Péter, et al.
Publicado: (2021)

Bracovirus Sneaks Into Apoptotic Bodies Transmitting Immunosuppressive Signaling Driven by Integration-Mediated eIF5A Hypusination
por: Zhou, Gui-Fang, et al.
Publicado: (2022)

TFEB and TFE3 control glucose homeostasis by regulating insulin gene expression
por: Pasquier, Adrien, et al.
Publicado: (2023)

Hypusinated eIF5A Promotes Ribosomal Frameshifting during Decoding of ODC Antizyme mRNA in Saccharomyces cerevisiae
por: Halwas, Kai, et al.
Publicado: (2022)

Inhibition of Eukaryotic Translation Initiation Factor 5A (eIF5A) Hypusination Suppress p53 Translation and Alters the Association of eIF5A to the Ribosomes
por: Martella, Marianna, et al.
Publicado: (2020)

TFEB-mTORC1 feedback loop in metabolism and cancer
por: Di Malta, Chiara, et al.
Publicado: (2017)

Hypusination Orchestrates the Antimicrobial Response of Macrophages
por: Gobert, Alain P., et al.
Publicado: (2020)

Renal Ischemia Tolerance Mediated by eIF5A Hypusination Inhibition Is Regulated by a Specific Modulation of the Endoplasmic Reticulum Stress
por: Melis, Nicolas, et al.
Publicado: (2023)

Cryo-EM structure of human eIF5A-DHS complex reveals the molecular basis of hypusination-associated neurodegenerative disorders
por: Wątor, Elżbieta, et al.
Publicado: (2023)

Specific and sensitive GC–MS analysis of hypusine, N(ε)-(4-amino-2-hydroxybutyl)lysine, a biomarker of hypusinated eukaryotic initiation factor eIF5A, and its application to the bi-ethnic ASOS study
por: Baskal, Svetlana, et al.
Publicado: (2022)

TFEB controls retromer expression in response to nutrient availability
por: Curnock, Rachel, et al.
Publicado: (2019)

Spermidine-mediated hypusination of translation factor EIF5A improves mitochondrial fatty acid oxidation and prevents non-alcoholic steatohepatitis progression
por: Zhou, Jin, et al.
Publicado: (2022)

New K50R mutant mouse models reveal impaired hypusination of eif5a2 with alterations in cell metabolite landscape
por: Schultz, Chad R., et al.
Publicado: (2023)

Expression of Eukaryotic Initiation Factor 5A and Hypusine Forming Enzymes in Glioblastoma Patient Samples: Implications for New Targeted Therapies
por: Preukschas, Michael, et al.
Publicado: (2012)

Autophagy-Dependent Generation of Free Fatty Acids Is Critical for Normal Neutrophil Differentiation
por: Riffelmacher, Thomas, et al.
Publicado: (2017)

Characterization of a novel polyclonal anti-hypusine antibody
por: Nishiki, Yurika, et al.
Publicado: (2013)

EGR1 drives cell proliferation by directly stimulating TFEB transcription in response to starvation
por: Cesana, Marcella, et al.
Publicado: (2023)

c-Abl Inhibition Activates TFEB and Promotes Cellular Clearance in a Lysosomal Disorder
por: Contreras, Pablo S., et al.
Publicado: (2020)

Spermidine protects against acute kidney injury by modulating macrophage NLRP3 inflammasome activation and mitochondrial respiration in an eIF5A hypusination-related pathway
por: Li, Xianzhi, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_rha66dj67bil8vp1dla6v6jve8