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UVB-Induced Tumor Heterogeneity Diminishes Immune Response in Melanoma
Although clonal neo-antigen burden is associated with improved response to immune therapy, the functional basis for this remains unclear. Here we study this question in a novel controlled mouse melanoma model that enables us to explore the effects of intra-tumor heterogeneity (ITH) on tumor aggressi...
Autores principales: | Wolf, Yochai, Bartok, Osnat, Patkar, Sushant, Eli, Gitit Bar, Cohen, Sapir, Litchfield, Kevin, Levy, Ronen, Jiménez-Sánchez, Alejandro, Trabish, Sophie, Lee, Joo Sang, Karathia, Hiren, Barnea, Eilon, Day, Chi-Ping, Cinnamon, Einat, Stein, Ilan, Solomon, Adam, Bitton, Lital, Pérez-Guijarro, Eva, Dubovik, Tania, Shen-Orr, Shai S., Miller, Martin L., Merlino, Glenn, Levin, Yishai, Pikarsky, Eli, Eisenbach, Lea, Admon, Arie, Swanton, Charles, Ruppin, Eytan, Samuels, Yardena |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cell Press
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6863386/ https://www.ncbi.nlm.nih.gov/pubmed/31522890 http://dx.doi.org/10.1016/j.cell.2019.08.032 |
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