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N-WASP Control of LPAR1 Trafficking Establishes Response to Self-Generated LPA Gradients to Promote Pancreatic Cancer Cell Metastasis

Pancreatic ductal adenocarcinoma is one of the most invasive and metastatic cancers and has a dismal 5-year survival rate. We show that N-WASP drives pancreatic cancer metastasis, with roles in both chemotaxis and matrix remodeling. lysophosphatidic acid, a signaling lipid abundant in blood and asci...

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Detalles Bibliográficos
Autores principales:	Juin, Amelie, Spence, Heather J., Martin, Kirsty J., McGhee, Ewan, Neilson, Matthew, Cutiongco, Marie F.A., Gadegaard, Nikolaj, Mackay, Gillian, Fort, Loic, Lilla, Sergio, Kalna, Gabriela, Thomason, Peter, Koh, Yvette W.H., Norman, Jim C., Insall, Robert H., Machesky, Laura M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6863394/ https://www.ncbi.nlm.nih.gov/pubmed/31668663 http://dx.doi.org/10.1016/j.devcel.2019.09.018

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