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SLX4IP Antagonizes Promiscuous BLM Activity during ALT Maintenance

Cancer cells acquire unlimited proliferative capacity by either re-expressing telomerase or inducing alternative lengthening of telomeres (ALT), which relies on telomere recombination. Here, we show that ALT recombination requires coordinate regulation of the SMX and BTR complexes to ensure the appr...

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Detalles Bibliográficos
Autores principales: Panier, Stephanie, Maric, Marija, Hewitt, Graeme, Mason-Osann, Emily, Gali, Himabindu, Dai, Anqi, Labadorf, Adam, Guervilly, Jean-Hugues, Ruis, Philip, Segura-Bayona, Sandra, Belan, Ondrej, Marzec, Paulina, Gaillard, Pierre-Henri L., Flynn, Rachel L., Boulton, Simon J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6863466/
https://www.ncbi.nlm.nih.gov/pubmed/31447390
http://dx.doi.org/10.1016/j.molcel.2019.07.010

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