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Motor cortex can directly drive the globus pallidus neurons in a projection neuron type-dependent manner in the rat

The basal ganglia are critical for the control of motor behaviors and for reinforcement learning. Here, we demonstrate in rats that primary and secondary motor areas (M1 and M2) make functional synaptic connections in the globus pallidus (GP), not usually thought of as an input site of the basal gan...

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Autores principales: Karube, Fuyuki, Takahashi, Susumu, Kobayashi, Kenta, Fujiyama, Fumino
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6863630/
https://www.ncbi.nlm.nih.gov/pubmed/31711567
http://dx.doi.org/10.7554/eLife.49511
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author Karube, Fuyuki
Takahashi, Susumu
Kobayashi, Kenta
Fujiyama, Fumino
author_facet Karube, Fuyuki
Takahashi, Susumu
Kobayashi, Kenta
Fujiyama, Fumino
author_sort Karube, Fuyuki
collection PubMed
description The basal ganglia are critical for the control of motor behaviors and for reinforcement learning. Here, we demonstrate in rats that primary and secondary motor areas (M1 and M2) make functional synaptic connections in the globus pallidus (GP), not usually thought of as an input site of the basal ganglia. Morphological observation revealed that the density of axonal boutons from motor cortices in the GP was 47% and 78% of that in the subthalamic nucleus (STN) from M1 and M2, respectively. Cortical excitation of GP neurons was comparable to that of STN neurons in slice preparations. FoxP2-expressing arkypallidal neurons were preferentially innervated by the motor cortex. The connection probability of cortico-pallidal innervation was higher for M2 than M1. These results suggest that cortico-pallidal innervation is an additional excitatory input to the basal ganglia, and that it can affect behaviors via the cortex-basal ganglia-thalamus motor loop.
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spelling pubmed-68636302019-11-20 Motor cortex can directly drive the globus pallidus neurons in a projection neuron type-dependent manner in the rat Karube, Fuyuki Takahashi, Susumu Kobayashi, Kenta Fujiyama, Fumino eLife Neuroscience The basal ganglia are critical for the control of motor behaviors and for reinforcement learning. Here, we demonstrate in rats that primary and secondary motor areas (M1 and M2) make functional synaptic connections in the globus pallidus (GP), not usually thought of as an input site of the basal ganglia. Morphological observation revealed that the density of axonal boutons from motor cortices in the GP was 47% and 78% of that in the subthalamic nucleus (STN) from M1 and M2, respectively. Cortical excitation of GP neurons was comparable to that of STN neurons in slice preparations. FoxP2-expressing arkypallidal neurons were preferentially innervated by the motor cortex. The connection probability of cortico-pallidal innervation was higher for M2 than M1. These results suggest that cortico-pallidal innervation is an additional excitatory input to the basal ganglia, and that it can affect behaviors via the cortex-basal ganglia-thalamus motor loop. eLife Sciences Publications, Ltd 2019-11-12 /pmc/articles/PMC6863630/ /pubmed/31711567 http://dx.doi.org/10.7554/eLife.49511 Text en © 2019, Karube et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Neuroscience
Karube, Fuyuki
Takahashi, Susumu
Kobayashi, Kenta
Fujiyama, Fumino
Motor cortex can directly drive the globus pallidus neurons in a projection neuron type-dependent manner in the rat
title Motor cortex can directly drive the globus pallidus neurons in a projection neuron type-dependent manner in the rat
title_full Motor cortex can directly drive the globus pallidus neurons in a projection neuron type-dependent manner in the rat
title_fullStr Motor cortex can directly drive the globus pallidus neurons in a projection neuron type-dependent manner in the rat
title_full_unstemmed Motor cortex can directly drive the globus pallidus neurons in a projection neuron type-dependent manner in the rat
title_short Motor cortex can directly drive the globus pallidus neurons in a projection neuron type-dependent manner in the rat
title_sort motor cortex can directly drive the globus pallidus neurons in a projection neuron type-dependent manner in the rat
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6863630/
https://www.ncbi.nlm.nih.gov/pubmed/31711567
http://dx.doi.org/10.7554/eLife.49511
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