Transcriptional responses of LSm14A after infection of blue eggshell layers with Newcastle disease viruses

LSm14A is a key innate immunity component of processing body (P-body) that mediates interferon-β (IFN-β) signaling by viral RNA. This is the first study to report chicken LSm14A (cLSm14A) cloning from blue eggshell layer, high tibia and frizzle chickens. The cLSm14A gene, encoding 461 amino acids, i...

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Autores principales: TIAN, Lang, WU, Changhua, WEN, Guilan, LI, Changhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Veterinary Science 2019
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6863722/
https://www.ncbi.nlm.nih.gov/pubmed/31534060
http://dx.doi.org/10.1292/jvms.19-0125
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author TIAN, Lang
WU, Changhua
WEN, Guilan
LI, Changhong
author_facet TIAN, Lang
WU, Changhua
WEN, Guilan
LI, Changhong
author_sort TIAN, Lang
collection PubMed
description LSm14A is a key innate immunity component of processing body (P-body) that mediates interferon-β (IFN-β) signaling by viral RNA. This is the first study to report chicken LSm14A (cLSm14A) cloning from blue eggshell layer, high tibia and frizzle chickens. The cLSm14A gene, encoding 461 amino acids, is highly homologous in the three types of chickens. The cLSm14A was extensively expressed in several tissues. The transcriptional level of cLSm14A was significantly increased in various stages of Newcastle disease virus (NDV) infection. In HEK293 cells, full length cLSm14A from blue eggshell layer was localized in the cytoplasm as dots. The results of this study indicated that cLSm14A is an important sensor that mediates innate immunity in chicken against NDV infections.
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spelling pubmed-68637222019-12-04 Transcriptional responses of LSm14A after infection of blue eggshell layers with Newcastle disease viruses TIAN, Lang WU, Changhua WEN, Guilan LI, Changhong J Vet Med Sci Immunology LSm14A is a key innate immunity component of processing body (P-body) that mediates interferon-β (IFN-β) signaling by viral RNA. This is the first study to report chicken LSm14A (cLSm14A) cloning from blue eggshell layer, high tibia and frizzle chickens. The cLSm14A gene, encoding 461 amino acids, is highly homologous in the three types of chickens. The cLSm14A was extensively expressed in several tissues. The transcriptional level of cLSm14A was significantly increased in various stages of Newcastle disease virus (NDV) infection. In HEK293 cells, full length cLSm14A from blue eggshell layer was localized in the cytoplasm as dots. The results of this study indicated that cLSm14A is an important sensor that mediates innate immunity in chicken against NDV infections. The Japanese Society of Veterinary Science 2019-09-18 2019-10 /pmc/articles/PMC6863722/ /pubmed/31534060 http://dx.doi.org/10.1292/jvms.19-0125 Text en ©2019 The Japanese Society of Veterinary Science This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Immunology
TIAN, Lang
WU, Changhua
WEN, Guilan
LI, Changhong
Transcriptional responses of LSm14A after infection of blue eggshell layers with Newcastle disease viruses
title Transcriptional responses of LSm14A after infection of blue eggshell layers with Newcastle disease viruses
title_full Transcriptional responses of LSm14A after infection of blue eggshell layers with Newcastle disease viruses
title_fullStr Transcriptional responses of LSm14A after infection of blue eggshell layers with Newcastle disease viruses
title_full_unstemmed Transcriptional responses of LSm14A after infection of blue eggshell layers with Newcastle disease viruses
title_short Transcriptional responses of LSm14A after infection of blue eggshell layers with Newcastle disease viruses
title_sort transcriptional responses of lsm14a after infection of blue eggshell layers with newcastle disease viruses
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6863722/
https://www.ncbi.nlm.nih.gov/pubmed/31534060
http://dx.doi.org/10.1292/jvms.19-0125
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AT wenguilan transcriptionalresponsesoflsm14aafterinfectionofblueeggshelllayerswithnewcastlediseaseviruses
AT lichanghong transcriptionalresponsesoflsm14aafterinfectionofblueeggshelllayerswithnewcastlediseaseviruses

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