Effect of food on the pharmacokinetics and therapeutic efficacy of 4-phenylbutyrate in progressive familial intrahepatic cholestasis

Progressive familial intrahepatic cholestasis (PFIC), a rare inherited disorder, progresses to liver failure in childhood. We have shown that sodium 4-phenylbutyrate (NaPB), a drug approved for urea cycle disorders (UCDs), has beneficial effects in PFIC. However, there is little evidence to determin...

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Detalles Bibliográficos
Autores principales: Nakano, Satoshi, Osaka, Shuhei, Sabu, Yusuke, Minowa, Kei, Hirai, Saeko, Kondou, Hiroki, Kimura, Takeshi, Azuma, Yoshihiro, Watanabe, Satoshi, Inui, Ayano, Bessho, Kazuhiko, Nakamura, Hidefumi, Kusano, Hironori, Nakazawa, Atsuko, Tanikawa, Ken, Kage, Masayoshi, Shimizu, Toshiaki, Kusuhara, Hiroyuki, Zen, Yoh, Suzuki, Mitsuyoshi, Hayashi, Hisamitsu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6863819/
https://www.ncbi.nlm.nih.gov/pubmed/31745229
http://dx.doi.org/10.1038/s41598-019-53628-x

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