Modulating multi-functional ERK complexes by covalent targeting of a recruitment site in vivo

Recently, the targeting of ERK with ATP-competitive inhibitors has emerged as a potential clinical strategy to overcome acquired resistance to BRAF and MEK inhibitor combination therapies. In this study, we investigate an alternative strategy of targeting the D-recruitment site (DRS) of ERK. The DRS...

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Detalles Bibliográficos
Autores principales: Kaoud, Tamer S., Johnson, William H., Ebelt, Nancy D., Piserchio, Andrea, Zamora-Olivares, Diana, Van Ravenstein, Sabrina X., Pridgen, Jacey R., Edupuganti, Ramakrishna, Sammons, Rachel, Cano, Micael, Warthaka, Mangalika, Harger, Matthew, Tavares, Clint D. J., Park, Jihyun, Radwan, Mohamed F., Ren, Pengyu, Anslyn, Eric V., Tsai, Kenneth Y., Ghose, Ranajeet, Dalby, Kevin N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6863825/
https://www.ncbi.nlm.nih.gov/pubmed/31745079
http://dx.doi.org/10.1038/s41467-019-12996-8

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