Plasticity of histone modifications around Cidea and Cidec genes with secondary bile in the amelioration of developmentally-programmed hepatic steatosis

We recently reported that a treatment with tauroursodeoxycholic acid (TUDCA), a secondary bile acid, improved developmentally-deteriorated hepatic steatosis in an undernourishment (UN, 40% caloric restriction) in utero mouse model after a postnatal high-fat diet (HFD). We performed a microarray anal...

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Autores principales: Urmi, Jeenat Ferdous, Itoh, Hiroaki, Muramatsu-Kato, Keiko, Kohmura-Kobayashi, Yukiko, Hariya, Natsuyo, Jain, Divyanu, Tamura, Naoaki, Uchida, Toshiyuki, Suzuki, Kazunao, Ogawa, Yoshihiro, Shiraki, Nobuaki, Mochizuki, Kazuki, Kubota, Takeo, Kanayama, Naohiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6863835/
https://www.ncbi.nlm.nih.gov/pubmed/31745102
http://dx.doi.org/10.1038/s41598-019-52943-7
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author Urmi, Jeenat Ferdous
Itoh, Hiroaki
Muramatsu-Kato, Keiko
Kohmura-Kobayashi, Yukiko
Hariya, Natsuyo
Jain, Divyanu
Tamura, Naoaki
Uchida, Toshiyuki
Suzuki, Kazunao
Ogawa, Yoshihiro
Shiraki, Nobuaki
Mochizuki, Kazuki
Kubota, Takeo
Kanayama, Naohiro
author_facet Urmi, Jeenat Ferdous
Itoh, Hiroaki
Muramatsu-Kato, Keiko
Kohmura-Kobayashi, Yukiko
Hariya, Natsuyo
Jain, Divyanu
Tamura, Naoaki
Uchida, Toshiyuki
Suzuki, Kazunao
Ogawa, Yoshihiro
Shiraki, Nobuaki
Mochizuki, Kazuki
Kubota, Takeo
Kanayama, Naohiro
author_sort Urmi, Jeenat Ferdous
collection PubMed
description We recently reported that a treatment with tauroursodeoxycholic acid (TUDCA), a secondary bile acid, improved developmentally-deteriorated hepatic steatosis in an undernourishment (UN, 40% caloric restriction) in utero mouse model after a postnatal high-fat diet (HFD). We performed a microarray analysis and focused on two genes (Cidea and Cidec) because they are enhancers of lipid droplet (LD) sizes in hepatocytes and showed the greatest up-regulation in expression by UN that were completely recovered by TUDCA, concomitant with parallel changes in LD sizes. TUDCA remodeled developmentally-induced histone modifications (dimethylation of H3K4, H3K27, or H3K36), but not DNA methylation, around the Cidea and Cidec genes in UN pups only. Changes in these histone modifications may contribute to the markedly down-regulated expression of Cidea and Cidec genes in UN pups, which was observed in the alleviation of hepatic fat deposition, even under HFD. These results provide an insight into the future of precision medicine for developmentally-programmed hepatic steatosis by targeting histone modifications.
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spelling pubmed-68638352019-11-20 Plasticity of histone modifications around Cidea and Cidec genes with secondary bile in the amelioration of developmentally-programmed hepatic steatosis Urmi, Jeenat Ferdous Itoh, Hiroaki Muramatsu-Kato, Keiko Kohmura-Kobayashi, Yukiko Hariya, Natsuyo Jain, Divyanu Tamura, Naoaki Uchida, Toshiyuki Suzuki, Kazunao Ogawa, Yoshihiro Shiraki, Nobuaki Mochizuki, Kazuki Kubota, Takeo Kanayama, Naohiro Sci Rep Article We recently reported that a treatment with tauroursodeoxycholic acid (TUDCA), a secondary bile acid, improved developmentally-deteriorated hepatic steatosis in an undernourishment (UN, 40% caloric restriction) in utero mouse model after a postnatal high-fat diet (HFD). We performed a microarray analysis and focused on two genes (Cidea and Cidec) because they are enhancers of lipid droplet (LD) sizes in hepatocytes and showed the greatest up-regulation in expression by UN that were completely recovered by TUDCA, concomitant with parallel changes in LD sizes. TUDCA remodeled developmentally-induced histone modifications (dimethylation of H3K4, H3K27, or H3K36), but not DNA methylation, around the Cidea and Cidec genes in UN pups only. Changes in these histone modifications may contribute to the markedly down-regulated expression of Cidea and Cidec genes in UN pups, which was observed in the alleviation of hepatic fat deposition, even under HFD. These results provide an insight into the future of precision medicine for developmentally-programmed hepatic steatosis by targeting histone modifications. Nature Publishing Group UK 2019-11-19 /pmc/articles/PMC6863835/ /pubmed/31745102 http://dx.doi.org/10.1038/s41598-019-52943-7 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Urmi, Jeenat Ferdous
Itoh, Hiroaki
Muramatsu-Kato, Keiko
Kohmura-Kobayashi, Yukiko
Hariya, Natsuyo
Jain, Divyanu
Tamura, Naoaki
Uchida, Toshiyuki
Suzuki, Kazunao
Ogawa, Yoshihiro
Shiraki, Nobuaki
Mochizuki, Kazuki
Kubota, Takeo
Kanayama, Naohiro
Plasticity of histone modifications around Cidea and Cidec genes with secondary bile in the amelioration of developmentally-programmed hepatic steatosis
title Plasticity of histone modifications around Cidea and Cidec genes with secondary bile in the amelioration of developmentally-programmed hepatic steatosis
title_full Plasticity of histone modifications around Cidea and Cidec genes with secondary bile in the amelioration of developmentally-programmed hepatic steatosis
title_fullStr Plasticity of histone modifications around Cidea and Cidec genes with secondary bile in the amelioration of developmentally-programmed hepatic steatosis
title_full_unstemmed Plasticity of histone modifications around Cidea and Cidec genes with secondary bile in the amelioration of developmentally-programmed hepatic steatosis
title_short Plasticity of histone modifications around Cidea and Cidec genes with secondary bile in the amelioration of developmentally-programmed hepatic steatosis
title_sort plasticity of histone modifications around cidea and cidec genes with secondary bile in the amelioration of developmentally-programmed hepatic steatosis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6863835/
https://www.ncbi.nlm.nih.gov/pubmed/31745102
http://dx.doi.org/10.1038/s41598-019-52943-7
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