Cargando…
Intraoperative Prediction Of Non-Sentinel Lymph Node Metastasis Based On The Molecular Assay In Breast Cancer Patients
PURPOSE: The aim of the study is to construct an intraoperative nomogram for the prediction of non-sentinel lymph node (NSLN) metastasis based on the one-step nucleic acid amplification assay in breast cancer patients. METHODS: A total of 552 patients were enrolled in the training study and 1090 pat...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6863878/ https://www.ncbi.nlm.nih.gov/pubmed/31814766 http://dx.doi.org/10.2147/CMAR.S226733 |
_version_ | 1783471781901762560 |
---|---|
author | Sun, Xiao Zhang, Yan Wu, Shuang Fu, Li Yun, Jing-Ping Wang, Yong-Sheng |
author_facet | Sun, Xiao Zhang, Yan Wu, Shuang Fu, Li Yun, Jing-Ping Wang, Yong-Sheng |
author_sort | Sun, Xiao |
collection | PubMed |
description | PURPOSE: The aim of the study is to construct an intraoperative nomogram for the prediction of non-sentinel lymph node (NSLN) metastasis based on the one-step nucleic acid amplification assay in breast cancer patients. METHODS: A total of 552 patients were enrolled in the training study and 1090 patients were enrolled in the validation study. The nomogram was constructed based on the molecular assay with logistic multivariate regression analysis in the training study and was validated in the validation study. RESULTS: A novel nomogram model was constructed with the total tumor load, the clinical primary tumor size, the number of positive and negative sentinel lymph nodes. The area under the receiver operating characteristic curve (AUC) of the model was 0.842. The AUC of the model which was sensitive to discern the patients with the stage of pN1 and ≥pN2 was 0.861. CONCLUSION: The nomogram model will help to guide the axillary management intraoperatively and precisely confirm the target region of radiotherapy postoperatively. |
format | Online Article Text |
id | pubmed-6863878 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-68638782019-12-06 Intraoperative Prediction Of Non-Sentinel Lymph Node Metastasis Based On The Molecular Assay In Breast Cancer Patients Sun, Xiao Zhang, Yan Wu, Shuang Fu, Li Yun, Jing-Ping Wang, Yong-Sheng Cancer Manag Res Original Research PURPOSE: The aim of the study is to construct an intraoperative nomogram for the prediction of non-sentinel lymph node (NSLN) metastasis based on the one-step nucleic acid amplification assay in breast cancer patients. METHODS: A total of 552 patients were enrolled in the training study and 1090 patients were enrolled in the validation study. The nomogram was constructed based on the molecular assay with logistic multivariate regression analysis in the training study and was validated in the validation study. RESULTS: A novel nomogram model was constructed with the total tumor load, the clinical primary tumor size, the number of positive and negative sentinel lymph nodes. The area under the receiver operating characteristic curve (AUC) of the model was 0.842. The AUC of the model which was sensitive to discern the patients with the stage of pN1 and ≥pN2 was 0.861. CONCLUSION: The nomogram model will help to guide the axillary management intraoperatively and precisely confirm the target region of radiotherapy postoperatively. Dove 2019-11-15 /pmc/articles/PMC6863878/ /pubmed/31814766 http://dx.doi.org/10.2147/CMAR.S226733 Text en © 2019 Sun et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Original Research Sun, Xiao Zhang, Yan Wu, Shuang Fu, Li Yun, Jing-Ping Wang, Yong-Sheng Intraoperative Prediction Of Non-Sentinel Lymph Node Metastasis Based On The Molecular Assay In Breast Cancer Patients |
title | Intraoperative Prediction Of Non-Sentinel Lymph Node Metastasis Based On The Molecular Assay In Breast Cancer Patients |
title_full | Intraoperative Prediction Of Non-Sentinel Lymph Node Metastasis Based On The Molecular Assay In Breast Cancer Patients |
title_fullStr | Intraoperative Prediction Of Non-Sentinel Lymph Node Metastasis Based On The Molecular Assay In Breast Cancer Patients |
title_full_unstemmed | Intraoperative Prediction Of Non-Sentinel Lymph Node Metastasis Based On The Molecular Assay In Breast Cancer Patients |
title_short | Intraoperative Prediction Of Non-Sentinel Lymph Node Metastasis Based On The Molecular Assay In Breast Cancer Patients |
title_sort | intraoperative prediction of non-sentinel lymph node metastasis based on the molecular assay in breast cancer patients |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6863878/ https://www.ncbi.nlm.nih.gov/pubmed/31814766 http://dx.doi.org/10.2147/CMAR.S226733 |
work_keys_str_mv | AT sunxiao intraoperativepredictionofnonsentinellymphnodemetastasisbasedonthemolecularassayinbreastcancerpatients AT zhangyan intraoperativepredictionofnonsentinellymphnodemetastasisbasedonthemolecularassayinbreastcancerpatients AT wushuang intraoperativepredictionofnonsentinellymphnodemetastasisbasedonthemolecularassayinbreastcancerpatients AT fuli intraoperativepredictionofnonsentinellymphnodemetastasisbasedonthemolecularassayinbreastcancerpatients AT yunjingping intraoperativepredictionofnonsentinellymphnodemetastasisbasedonthemolecularassayinbreastcancerpatients AT wangyongsheng intraoperativepredictionofnonsentinellymphnodemetastasisbasedonthemolecularassayinbreastcancerpatients |