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Epigenetic Regulation in the Pathogenesis of Sjögren Syndrome and Rheumatoid Arthritis

Autoimmune rheumatic diseases, such as Sjögren syndrome (SS) and rheumatoid arthritis (RA), are characterized by chronic inflammation and autoimmunity, which cause joint tissue damage and destruction by triggering reduced mobility and debilitation in patients with these diseases. Initiation and main...

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Autores principales: Ibáñez-Cabellos, José Santiago, Seco-Cervera, Marta, Osca-Verdegal, Rebeca, Pallardó, Federico V., García-Giménez, José Luis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6863924/
https://www.ncbi.nlm.nih.gov/pubmed/31798626
http://dx.doi.org/10.3389/fgene.2019.01104
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author Ibáñez-Cabellos, José Santiago
Seco-Cervera, Marta
Osca-Verdegal, Rebeca
Pallardó, Federico V.
García-Giménez, José Luis
author_facet Ibáñez-Cabellos, José Santiago
Seco-Cervera, Marta
Osca-Verdegal, Rebeca
Pallardó, Federico V.
García-Giménez, José Luis
author_sort Ibáñez-Cabellos, José Santiago
collection PubMed
description Autoimmune rheumatic diseases, such as Sjögren syndrome (SS) and rheumatoid arthritis (RA), are characterized by chronic inflammation and autoimmunity, which cause joint tissue damage and destruction by triggering reduced mobility and debilitation in patients with these diseases. Initiation and maintenance of chronic inflammatory stages account for several mechanisms that involve immune cells as key players and the interaction of the immune cells with other tissues. Indeed, the overlapping of certain clinical and serologic manifestations between SS and RA may indicate that numerous immunologic-related mechanisms are involved in the physiopathology of both these diseases. It is widely accepted that epigenetic pathways play an essential role in the development and function of the immune system. Although many published studies have attempted to elucidate the relation between epigenetic modifications (e.g. DNA methylation, histone post-translational modifications, miRNAs) and autoimmune disorders, the contribution of epigenetic regulation to the pathogenesis of SS and RA is at present poorly understood. This review attempts to shed light from a critical point of view on the identification of the most relevant epigenetic mechanisms related to RA and SS by explaining intricate regulatory processes and phenotypic features of both autoimmune diseases. Moreover, we point out some epigenetic markers which can be used to monitor the inflammation status and the dysregulated immunity in SS and RA. Finally, we discuss the inconvenience of using epigenetic data obtained from bulk immune cell populations instead specific immune cell subpopulations.
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spelling pubmed-68639242019-12-03 Epigenetic Regulation in the Pathogenesis of Sjögren Syndrome and Rheumatoid Arthritis Ibáñez-Cabellos, José Santiago Seco-Cervera, Marta Osca-Verdegal, Rebeca Pallardó, Federico V. García-Giménez, José Luis Front Genet Genetics Autoimmune rheumatic diseases, such as Sjögren syndrome (SS) and rheumatoid arthritis (RA), are characterized by chronic inflammation and autoimmunity, which cause joint tissue damage and destruction by triggering reduced mobility and debilitation in patients with these diseases. Initiation and maintenance of chronic inflammatory stages account for several mechanisms that involve immune cells as key players and the interaction of the immune cells with other tissues. Indeed, the overlapping of certain clinical and serologic manifestations between SS and RA may indicate that numerous immunologic-related mechanisms are involved in the physiopathology of both these diseases. It is widely accepted that epigenetic pathways play an essential role in the development and function of the immune system. Although many published studies have attempted to elucidate the relation between epigenetic modifications (e.g. DNA methylation, histone post-translational modifications, miRNAs) and autoimmune disorders, the contribution of epigenetic regulation to the pathogenesis of SS and RA is at present poorly understood. This review attempts to shed light from a critical point of view on the identification of the most relevant epigenetic mechanisms related to RA and SS by explaining intricate regulatory processes and phenotypic features of both autoimmune diseases. Moreover, we point out some epigenetic markers which can be used to monitor the inflammation status and the dysregulated immunity in SS and RA. Finally, we discuss the inconvenience of using epigenetic data obtained from bulk immune cell populations instead specific immune cell subpopulations. Frontiers Media S.A. 2019-11-13 /pmc/articles/PMC6863924/ /pubmed/31798626 http://dx.doi.org/10.3389/fgene.2019.01104 Text en Copyright © 2019 Ibáñez-Cabellos, Seco-Cervera, Osca-Verdegal, Pallardó and García-Giménez http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Ibáñez-Cabellos, José Santiago
Seco-Cervera, Marta
Osca-Verdegal, Rebeca
Pallardó, Federico V.
García-Giménez, José Luis
Epigenetic Regulation in the Pathogenesis of Sjögren Syndrome and Rheumatoid Arthritis
title Epigenetic Regulation in the Pathogenesis of Sjögren Syndrome and Rheumatoid Arthritis
title_full Epigenetic Regulation in the Pathogenesis of Sjögren Syndrome and Rheumatoid Arthritis
title_fullStr Epigenetic Regulation in the Pathogenesis of Sjögren Syndrome and Rheumatoid Arthritis
title_full_unstemmed Epigenetic Regulation in the Pathogenesis of Sjögren Syndrome and Rheumatoid Arthritis
title_short Epigenetic Regulation in the Pathogenesis of Sjögren Syndrome and Rheumatoid Arthritis
title_sort epigenetic regulation in the pathogenesis of sjögren syndrome and rheumatoid arthritis
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6863924/
https://www.ncbi.nlm.nih.gov/pubmed/31798626
http://dx.doi.org/10.3389/fgene.2019.01104
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