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Quantitation of a Novel Engineered Anti-infective Host Defense Peptide, ARV-1502: Pharmacokinetic Study of Different Doses in Rats and Dogs

The designer proline-rich antimicrobial peptide (PrAMP) Chex1-Arg20 amide (ARV-1502) is active against Gram-negative and Gram-positive pathogens in different murine infection models when administered parenterally and possesses a wide therapeutic index. Here we studied the pharmacokinetics of ARV-150...

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Detalles Bibliográficos
Autores principales:	Brakel, Alexandra, Volke, Daniela, Kraus, Carl N., Otvos, Laszlo, Hoffmann, Ralf
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6863955/ https://www.ncbi.nlm.nih.gov/pubmed/31799234 http://dx.doi.org/10.3389/fchem.2019.00753

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