Transposable element expression in tumors is associated with immune infiltration and increased antigenicity

Profound global loss of DNA methylation is a hallmark of many cancers. One potential consequence of this is the reactivation of transposable elements (TEs) which could stimulate the immune system via cell-intrinsic antiviral responses. Here, we develop REdiscoverTE, a computational method for quanti...

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Detalles Bibliográficos
Autores principales: Kong, Yu, Rose, Christopher M., Cass, Ashley A., Williams, Alexander G., Darwish, Martine, Lianoglou, Steve, Haverty, Peter M., Tong, Ann-Jay, Blanchette, Craig, Albert, Matthew L., Mellman, Ira, Bourgon, Richard, Greally, John, Jhunjhunwala, Suchit, Chen-Harris, Haiyin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6864081/
https://www.ncbi.nlm.nih.gov/pubmed/31745090
http://dx.doi.org/10.1038/s41467-019-13035-2

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