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Evaluation of nanoselenium and nanogold activities against murine intestinal schistosomiasis

Nanomedicine is one of the most important methods used to treat human diseases including parasitic diseases. Schistosomiasis is a major parasitic disease that affects human health in tropical regions. Whilst Praziquantel is the main classic antischistosomal drug, new drugs are required due to the po...

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Autores principales: Dkhil, Mohamed A., Khalil, Mona F., Diab, Marwa S.M., Bauomy, Amira A., Santourlidis, Simeon, Al-Shaebi, Esam M., Al-Quraishy, Saleh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6864191/
https://www.ncbi.nlm.nih.gov/pubmed/31762611
http://dx.doi.org/10.1016/j.sjbs.2018.02.008
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author Dkhil, Mohamed A.
Khalil, Mona F.
Diab, Marwa S.M.
Bauomy, Amira A.
Santourlidis, Simeon
Al-Shaebi, Esam M.
Al-Quraishy, Saleh
author_facet Dkhil, Mohamed A.
Khalil, Mona F.
Diab, Marwa S.M.
Bauomy, Amira A.
Santourlidis, Simeon
Al-Shaebi, Esam M.
Al-Quraishy, Saleh
author_sort Dkhil, Mohamed A.
collection PubMed
description Nanomedicine is one of the most important methods used to treat human diseases including parasitic diseases. Schistosomiasis is a major parasitic disease that affects human health in tropical regions. Whilst Praziquantel is the main classic antischistosomal drug, new drugs are required due to the poor effect of the drug on the parasite juveniles and immature worms, and the emergence of drug resistant strains of Schistosoma. The present study aimed to examine the curative roles of both gold and selenium nanoparticles on jejunal tissues of mice infected with Schistosoma mansoni. Transmission electron microscopy was used for characterization of nanoparticles. Gold nanoparticles of 1 mg/kg mice body weight and selenium nanoparticles 0.5 mg/kg body weight were inoculated separately into mice infected with S. mansoni. The parasite induced a significant decrease in glutathione levels; however, the levels of nitric oxide and malondialdehyde were significantly increased. Additionally, the parasite introduced deteriorations in histological architecture of the jejunal tissue. Treatment of mice with metal nanoparticles reduced the levels of body weight changes, oxidative stress and histological impairment in the jejunal tissue significantly. Therefore, our results revealed the protective role of both selenium and gold nanoparticles against jejunal injury in mice infected with S. mansoni.
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spelling pubmed-68641912019-11-22 Evaluation of nanoselenium and nanogold activities against murine intestinal schistosomiasis Dkhil, Mohamed A. Khalil, Mona F. Diab, Marwa S.M. Bauomy, Amira A. Santourlidis, Simeon Al-Shaebi, Esam M. Al-Quraishy, Saleh Saudi J Biol Sci Article Nanomedicine is one of the most important methods used to treat human diseases including parasitic diseases. Schistosomiasis is a major parasitic disease that affects human health in tropical regions. Whilst Praziquantel is the main classic antischistosomal drug, new drugs are required due to the poor effect of the drug on the parasite juveniles and immature worms, and the emergence of drug resistant strains of Schistosoma. The present study aimed to examine the curative roles of both gold and selenium nanoparticles on jejunal tissues of mice infected with Schistosoma mansoni. Transmission electron microscopy was used for characterization of nanoparticles. Gold nanoparticles of 1 mg/kg mice body weight and selenium nanoparticles 0.5 mg/kg body weight were inoculated separately into mice infected with S. mansoni. The parasite induced a significant decrease in glutathione levels; however, the levels of nitric oxide and malondialdehyde were significantly increased. Additionally, the parasite introduced deteriorations in histological architecture of the jejunal tissue. Treatment of mice with metal nanoparticles reduced the levels of body weight changes, oxidative stress and histological impairment in the jejunal tissue significantly. Therefore, our results revealed the protective role of both selenium and gold nanoparticles against jejunal injury in mice infected with S. mansoni. Elsevier 2019-11 2018-02-21 /pmc/articles/PMC6864191/ /pubmed/31762611 http://dx.doi.org/10.1016/j.sjbs.2018.02.008 Text en © 2018 King Saud University http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Dkhil, Mohamed A.
Khalil, Mona F.
Diab, Marwa S.M.
Bauomy, Amira A.
Santourlidis, Simeon
Al-Shaebi, Esam M.
Al-Quraishy, Saleh
Evaluation of nanoselenium and nanogold activities against murine intestinal schistosomiasis
title Evaluation of nanoselenium and nanogold activities against murine intestinal schistosomiasis
title_full Evaluation of nanoselenium and nanogold activities against murine intestinal schistosomiasis
title_fullStr Evaluation of nanoselenium and nanogold activities against murine intestinal schistosomiasis
title_full_unstemmed Evaluation of nanoselenium and nanogold activities against murine intestinal schistosomiasis
title_short Evaluation of nanoselenium and nanogold activities against murine intestinal schistosomiasis
title_sort evaluation of nanoselenium and nanogold activities against murine intestinal schistosomiasis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6864191/
https://www.ncbi.nlm.nih.gov/pubmed/31762611
http://dx.doi.org/10.1016/j.sjbs.2018.02.008
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