Potential Interplay between Dietary Saturated Fats and Genetic Variants of the NLRP3 Inflammasome to Modulate Insulin Resistance and Diabetes Risk: Insights from a Meta‐Analysis of 19 005 Individuals

SCOPE: Insulin resistance (IR) and inflammation are hallmarks of type 2 diabetes (T2D). The nod‐like receptor pyrin domain containing‐3 (NLRP3) inflammasome is a metabolic sensor activated by saturated fatty acids (SFA) initiating IL‐1β inflammation and IR. Interactions between SFA intake and NLRP3‐...

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Detalles Bibliográficos
Autores principales: Murphy, Aoife M., Smith, Caren E., Murphy, Leanne M., Follis, Jack L., Tanaka, Toshiko, Richardson, Kris, Noordam, Raymond, Lemaitre, Rozenn N., Kähönen, Mika, Dupuis, Josée, Voortman, Trudy, Marouli, Eirini, Mook‐Kanamori, Dennis O., Raitakari, Olli T., Hong, Jaeyoung, Dehghan, Abbas, Dedoussis, George, de Mutsert, Renée, Lehtimäki, Terho, Liu, Ching‐Ti, Rivadeneira, Fernando, Deloukas, Panagiotis, Mikkilä, Vera, Meigs, James B., Uitterlinden, Andre, Ikram, Mohammad A., Franco, Oscar H., Hughes, Maria, O' Gaora, Peadar, Ordovás, José M., Roche, Helen M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6864231/
https://www.ncbi.nlm.nih.gov/pubmed/31432628
http://dx.doi.org/10.1002/mnfr.201900226

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