Impact of oxidative posttranslational modifications of SERCA2 on heart failure exacerbation in young patients with non-ischemic cardiomyopathy: A pilot study

BACKGROUND: Oxidative posttranslational modifications (OPTM) impair the function of Sarcoplasmic/endoplasmic reticulum (SR) calcium (Ca(2+)) ATPase (SERCA) 2 and trigger cytosolic Ca(2+) dysregulation. We investigated the extent of OPTM of SERCA2 in patients with non-ischemic cardiomyopathy (NICM)....

Descripción completa

Detalles Bibliográficos
Autores principales: Toya, Takumi, Ito, Kei, Kagami, Kazuki, Osaki, Ayumu, Sato, Atsushi, Kimura, Toyokazu, Horii, Shunpei, Yasuda, Risako, Namba, Takayuki, Ido, Yasuo, Nagatomo, Yuji, Hayashi, Katsumi, Masaki, Nobuyuki, Yada, Hirotaka, Adachi, Takeshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6864308/
https://www.ncbi.nlm.nih.gov/pubmed/31763443
http://dx.doi.org/10.1016/j.ijcha.2019.100437

Ejemplares similares

Ejemplares similares