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Gamma Irradiated Rhodiola sachalinensis Extract Ameliorates Testosterone-Induced Benign Prostatic Hyperplasia by Downregulating 5-Alpha Reductase and Restoring Testosterone in Rats

The effect of Rhodiola sachalinensis Boriss extract irradiated with 50 kGy gamma rays (HKC) on benign prostatic hyperplasia (BPH) was investigated. Seven-week-old male SD rats received a subcutaneous injection of 20 mg/kg of testosterone propionate (TP) to induce BPH. Then, the testosterone only gro...

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Autores principales: Xin, Qi, Kwon, Mi-Jin, Lee, Ju-Woon, Kim, Kwan-Soo, Chen, Hao, Campos, Maria G., Tundis, Rosa, Cui, Cheng-Bi, Cho, Young Ho, Cao, Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6864434/
https://www.ncbi.nlm.nih.gov/pubmed/31689885
http://dx.doi.org/10.3390/molecules24213981
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author Xin, Qi
Kwon, Mi-Jin
Lee, Ju-Woon
Kim, Kwan-Soo
Chen, Hao
Campos, Maria G.
Tundis, Rosa
Cui, Cheng-Bi
Cho, Young Ho
Cao, Hui
author_facet Xin, Qi
Kwon, Mi-Jin
Lee, Ju-Woon
Kim, Kwan-Soo
Chen, Hao
Campos, Maria G.
Tundis, Rosa
Cui, Cheng-Bi
Cho, Young Ho
Cao, Hui
author_sort Xin, Qi
collection PubMed
description The effect of Rhodiola sachalinensis Boriss extract irradiated with 50 kGy gamma rays (HKC) on benign prostatic hyperplasia (BPH) was investigated. Seven-week-old male SD rats received a subcutaneous injection of 20 mg/kg of testosterone propionate (TP) to induce BPH. Then, the testosterone only group received testosterone, the testosterone + finasteride group received testosterone and finasteride (5 mg/kg), the testosterone + HKC group received testosterone and HKC extract (500 mg/kg). Prostate weight and the dihydrotestosterone (DHT) levels in serum or prostate tissue were determined. The mRNA expressions of 5-alpha reductase (AR) in prostate tissue were also measured. Compared to the control group, prostate weight was significantly improved in the TP group and decreased in the HKC and finasteride-treated groups. Furthermore, the mRNA expression of 5-AR in the prostate was significantly reduced in the HKC and finasteride-treated groups. Similarly, the expression levels of α-smooth muscle actin (α-SMA) and cytokeratin, which are associated with prostatic enlargement in the HKC and finasteride groups, were much lower than in the TP group. HKC treatment showed similar efficacy to finasteride treatment on rats with testosterone-induced BPH. HKC may be explored as a potential new drug for BPH treatment.
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spelling pubmed-68644342019-12-23 Gamma Irradiated Rhodiola sachalinensis Extract Ameliorates Testosterone-Induced Benign Prostatic Hyperplasia by Downregulating 5-Alpha Reductase and Restoring Testosterone in Rats Xin, Qi Kwon, Mi-Jin Lee, Ju-Woon Kim, Kwan-Soo Chen, Hao Campos, Maria G. Tundis, Rosa Cui, Cheng-Bi Cho, Young Ho Cao, Hui Molecules Article The effect of Rhodiola sachalinensis Boriss extract irradiated with 50 kGy gamma rays (HKC) on benign prostatic hyperplasia (BPH) was investigated. Seven-week-old male SD rats received a subcutaneous injection of 20 mg/kg of testosterone propionate (TP) to induce BPH. Then, the testosterone only group received testosterone, the testosterone + finasteride group received testosterone and finasteride (5 mg/kg), the testosterone + HKC group received testosterone and HKC extract (500 mg/kg). Prostate weight and the dihydrotestosterone (DHT) levels in serum or prostate tissue were determined. The mRNA expressions of 5-alpha reductase (AR) in prostate tissue were also measured. Compared to the control group, prostate weight was significantly improved in the TP group and decreased in the HKC and finasteride-treated groups. Furthermore, the mRNA expression of 5-AR in the prostate was significantly reduced in the HKC and finasteride-treated groups. Similarly, the expression levels of α-smooth muscle actin (α-SMA) and cytokeratin, which are associated with prostatic enlargement in the HKC and finasteride groups, were much lower than in the TP group. HKC treatment showed similar efficacy to finasteride treatment on rats with testosterone-induced BPH. HKC may be explored as a potential new drug for BPH treatment. MDPI 2019-11-04 /pmc/articles/PMC6864434/ /pubmed/31689885 http://dx.doi.org/10.3390/molecules24213981 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Xin, Qi
Kwon, Mi-Jin
Lee, Ju-Woon
Kim, Kwan-Soo
Chen, Hao
Campos, Maria G.
Tundis, Rosa
Cui, Cheng-Bi
Cho, Young Ho
Cao, Hui
Gamma Irradiated Rhodiola sachalinensis Extract Ameliorates Testosterone-Induced Benign Prostatic Hyperplasia by Downregulating 5-Alpha Reductase and Restoring Testosterone in Rats
title Gamma Irradiated Rhodiola sachalinensis Extract Ameliorates Testosterone-Induced Benign Prostatic Hyperplasia by Downregulating 5-Alpha Reductase and Restoring Testosterone in Rats
title_full Gamma Irradiated Rhodiola sachalinensis Extract Ameliorates Testosterone-Induced Benign Prostatic Hyperplasia by Downregulating 5-Alpha Reductase and Restoring Testosterone in Rats
title_fullStr Gamma Irradiated Rhodiola sachalinensis Extract Ameliorates Testosterone-Induced Benign Prostatic Hyperplasia by Downregulating 5-Alpha Reductase and Restoring Testosterone in Rats
title_full_unstemmed Gamma Irradiated Rhodiola sachalinensis Extract Ameliorates Testosterone-Induced Benign Prostatic Hyperplasia by Downregulating 5-Alpha Reductase and Restoring Testosterone in Rats
title_short Gamma Irradiated Rhodiola sachalinensis Extract Ameliorates Testosterone-Induced Benign Prostatic Hyperplasia by Downregulating 5-Alpha Reductase and Restoring Testosterone in Rats
title_sort gamma irradiated rhodiola sachalinensis extract ameliorates testosterone-induced benign prostatic hyperplasia by downregulating 5-alpha reductase and restoring testosterone in rats
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6864434/
https://www.ncbi.nlm.nih.gov/pubmed/31689885
http://dx.doi.org/10.3390/molecules24213981
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