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Catalyst-Free Synthesis of Polysubstituted 5-Acylamino-1,3-Thiazoles via Hantzsch Cyclization of α-Chloroglycinates
A catalyst-free heterocyclization reaction of α-chloroglycinates with thiobenzamides or thioureas leading to 2,4-disubstituted-5-acylamino-1,3-thiazoles has been developed. The methodology provides straightforward access to valuable building blocks for pharmaceutically relevant compounds.
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6864457/ https://www.ncbi.nlm.nih.gov/pubmed/31731437 http://dx.doi.org/10.3390/molecules24213846 |
| _version_ | 1783471887149432832 |
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| author | Tomassetti, Mara Lupidi, Gabriele Piermattei, Pamela Rossi, Federico V. Lillini, Samuele Bianchini, Gianluca Aramini, Andrea Ciufolini, Marco A. Marcantoni, Enrico |
| author_facet | Tomassetti, Mara Lupidi, Gabriele Piermattei, Pamela Rossi, Federico V. Lillini, Samuele Bianchini, Gianluca Aramini, Andrea Ciufolini, Marco A. Marcantoni, Enrico |
| author_sort | Tomassetti, Mara |
| collection | PubMed |
| description | A catalyst-free heterocyclization reaction of α-chloroglycinates with thiobenzamides or thioureas leading to 2,4-disubstituted-5-acylamino-1,3-thiazoles has been developed. The methodology provides straightforward access to valuable building blocks for pharmaceutically relevant compounds. |
| format | Online Article Text |
| id | pubmed-6864457 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2019 |
| publisher | MDPI |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-68644572019-12-23 Catalyst-Free Synthesis of Polysubstituted 5-Acylamino-1,3-Thiazoles via Hantzsch Cyclization of α-Chloroglycinates Tomassetti, Mara Lupidi, Gabriele Piermattei, Pamela Rossi, Federico V. Lillini, Samuele Bianchini, Gianluca Aramini, Andrea Ciufolini, Marco A. Marcantoni, Enrico Molecules Article A catalyst-free heterocyclization reaction of α-chloroglycinates with thiobenzamides or thioureas leading to 2,4-disubstituted-5-acylamino-1,3-thiazoles has been developed. The methodology provides straightforward access to valuable building blocks for pharmaceutically relevant compounds. MDPI 2019-10-25 /pmc/articles/PMC6864457/ /pubmed/31731437 http://dx.doi.org/10.3390/molecules24213846 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
| spellingShingle | Article Tomassetti, Mara Lupidi, Gabriele Piermattei, Pamela Rossi, Federico V. Lillini, Samuele Bianchini, Gianluca Aramini, Andrea Ciufolini, Marco A. Marcantoni, Enrico Catalyst-Free Synthesis of Polysubstituted 5-Acylamino-1,3-Thiazoles via Hantzsch Cyclization of α-Chloroglycinates |
| title | Catalyst-Free Synthesis of Polysubstituted 5-Acylamino-1,3-Thiazoles via Hantzsch Cyclization of α-Chloroglycinates |
| title_full | Catalyst-Free Synthesis of Polysubstituted 5-Acylamino-1,3-Thiazoles via Hantzsch Cyclization of α-Chloroglycinates |
| title_fullStr | Catalyst-Free Synthesis of Polysubstituted 5-Acylamino-1,3-Thiazoles via Hantzsch Cyclization of α-Chloroglycinates |
| title_full_unstemmed | Catalyst-Free Synthesis of Polysubstituted 5-Acylamino-1,3-Thiazoles via Hantzsch Cyclization of α-Chloroglycinates |
| title_short | Catalyst-Free Synthesis of Polysubstituted 5-Acylamino-1,3-Thiazoles via Hantzsch Cyclization of α-Chloroglycinates |
| title_sort | catalyst-free synthesis of polysubstituted 5-acylamino-1,3-thiazoles via hantzsch cyclization of α-chloroglycinates |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6864457/ https://www.ncbi.nlm.nih.gov/pubmed/31731437 http://dx.doi.org/10.3390/molecules24213846 |
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