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Catalyst-Free Synthesis of Polysubstituted 5-Acylamino-1,3-Thiazoles via Hantzsch Cyclization of α-Chloroglycinates

A catalyst-free heterocyclization reaction of α-chloroglycinates with thiobenzamides or thioureas leading to 2,4-disubstituted-5-acylamino-1,3-thiazoles has been developed. The methodology provides straightforward access to valuable building blocks for pharmaceutically relevant compounds.

Detalles Bibliográficos
Autores principales:	Tomassetti, Mara, Lupidi, Gabriele, Piermattei, Pamela, Rossi, Federico V., Lillini, Samuele, Bianchini, Gianluca, Aramini, Andrea, Ciufolini, Marco A., Marcantoni, Enrico
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6864457/ https://www.ncbi.nlm.nih.gov/pubmed/31731437 http://dx.doi.org/10.3390/molecules24213846

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