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Smart H(2)S‐Triggered/Therapeutic System (SHTS)‐Based Nanomedicine
Hydrogen sulfide (H(2)S) is of vital importance in several biological and physical processes. The significance of H(2)S‐specific detection and monitoring is emphasized by its elevated levels in various diseases such as cancer. Nanotechnology enhances the performance of chemical sensing nanoprobes du...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6864508/ https://www.ncbi.nlm.nih.gov/pubmed/31763153 http://dx.doi.org/10.1002/advs.201901724 |
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author | Chen, Weiyu Ni, Dalong Rosenkrans, Zachary T. Cao, Tianye Cai, Weibo |
author_facet | Chen, Weiyu Ni, Dalong Rosenkrans, Zachary T. Cao, Tianye Cai, Weibo |
author_sort | Chen, Weiyu |
collection | PubMed |
description | Hydrogen sulfide (H(2)S) is of vital importance in several biological and physical processes. The significance of H(2)S‐specific detection and monitoring is emphasized by its elevated levels in various diseases such as cancer. Nanotechnology enhances the performance of chemical sensing nanoprobes due to the enhanced efficiency and sensitivity. Recently, extensive research efforts have been dedicated to developing novel smart H(2)S‐triggered/therapeutic system (SHTS) nanoplatforms for H(2)S‐activated sensing, imaging, and therapy. Herein, the latest SHTS‐based nanomaterials are summarized and discussed in detail. In addition, therapeutic strategies mediated by endogenous H(2)S as a trigger or exogenous H(2)S delivery are also included. A comprehensive understanding of the current status of SHTS‐based strategies will greatly facilitate innovation in this field. Lastly, the challenges and key issues related to the design and development of SHTS‐based nanomaterials (e.g., morphology, surface modification, therapeutic strategies, appropriate application, and selection of nanomaterials) are outlined. |
format | Online Article Text |
id | pubmed-6864508 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-68645082019-11-22 Smart H(2)S‐Triggered/Therapeutic System (SHTS)‐Based Nanomedicine Chen, Weiyu Ni, Dalong Rosenkrans, Zachary T. Cao, Tianye Cai, Weibo Adv Sci (Weinh) Reviews Hydrogen sulfide (H(2)S) is of vital importance in several biological and physical processes. The significance of H(2)S‐specific detection and monitoring is emphasized by its elevated levels in various diseases such as cancer. Nanotechnology enhances the performance of chemical sensing nanoprobes due to the enhanced efficiency and sensitivity. Recently, extensive research efforts have been dedicated to developing novel smart H(2)S‐triggered/therapeutic system (SHTS) nanoplatforms for H(2)S‐activated sensing, imaging, and therapy. Herein, the latest SHTS‐based nanomaterials are summarized and discussed in detail. In addition, therapeutic strategies mediated by endogenous H(2)S as a trigger or exogenous H(2)S delivery are also included. A comprehensive understanding of the current status of SHTS‐based strategies will greatly facilitate innovation in this field. Lastly, the challenges and key issues related to the design and development of SHTS‐based nanomaterials (e.g., morphology, surface modification, therapeutic strategies, appropriate application, and selection of nanomaterials) are outlined. John Wiley and Sons Inc. 2019-10-14 /pmc/articles/PMC6864508/ /pubmed/31763153 http://dx.doi.org/10.1002/advs.201901724 Text en © 2019 The Authors. Published by WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Reviews Chen, Weiyu Ni, Dalong Rosenkrans, Zachary T. Cao, Tianye Cai, Weibo Smart H(2)S‐Triggered/Therapeutic System (SHTS)‐Based Nanomedicine |
title | Smart H(2)S‐Triggered/Therapeutic System (SHTS)‐Based Nanomedicine |
title_full | Smart H(2)S‐Triggered/Therapeutic System (SHTS)‐Based Nanomedicine |
title_fullStr | Smart H(2)S‐Triggered/Therapeutic System (SHTS)‐Based Nanomedicine |
title_full_unstemmed | Smart H(2)S‐Triggered/Therapeutic System (SHTS)‐Based Nanomedicine |
title_short | Smart H(2)S‐Triggered/Therapeutic System (SHTS)‐Based Nanomedicine |
title_sort | smart h(2)s‐triggered/therapeutic system (shts)‐based nanomedicine |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6864508/ https://www.ncbi.nlm.nih.gov/pubmed/31763153 http://dx.doi.org/10.1002/advs.201901724 |
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