Towards a System for Tracking Drug Delivery Using Frequency Excited Gold Nanoparticles

Nanoparticle-based drugs are rapidly evolving to treat different conditions and have considerable potential. A new system based on the combination of electrical impedance tomography (EIT) imaging and a power amplifier with a RF coil has been developed to study the effect of gold nanoparticles (AuNPs...

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Autores principales: Neshatvar, Nazanin, Damaso, Rui, Seifnaraghi, Nima, Demosthenous, Andreas, Bayford, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6864618/
https://www.ncbi.nlm.nih.gov/pubmed/31683843
http://dx.doi.org/10.3390/s19214750
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author Neshatvar, Nazanin
Damaso, Rui
Seifnaraghi, Nima
Demosthenous, Andreas
Bayford, Richard
author_facet Neshatvar, Nazanin
Damaso, Rui
Seifnaraghi, Nima
Demosthenous, Andreas
Bayford, Richard
author_sort Neshatvar, Nazanin
collection PubMed
description Nanoparticle-based drugs are rapidly evolving to treat different conditions and have considerable potential. A new system based on the combination of electrical impedance tomography (EIT) imaging and a power amplifier with a RF coil has been developed to study the effect of gold nanoparticles (AuNPs) when excited in the MHz frequency range. We show that samples including AuNPs have a temperature increase of 1–1.5 °C due to the presence of RF excitation at 13.56 MHz which provides a higher rate of change for solutions without AuNPs. They also show more than a 50% increase in conductivity in difference imaging as the result of this excitation. The change for samples without AuNPs is 40%.
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spelling pubmed-68646182019-12-23 Towards a System for Tracking Drug Delivery Using Frequency Excited Gold Nanoparticles Neshatvar, Nazanin Damaso, Rui Seifnaraghi, Nima Demosthenous, Andreas Bayford, Richard Sensors (Basel) Article Nanoparticle-based drugs are rapidly evolving to treat different conditions and have considerable potential. A new system based on the combination of electrical impedance tomography (EIT) imaging and a power amplifier with a RF coil has been developed to study the effect of gold nanoparticles (AuNPs) when excited in the MHz frequency range. We show that samples including AuNPs have a temperature increase of 1–1.5 °C due to the presence of RF excitation at 13.56 MHz which provides a higher rate of change for solutions without AuNPs. They also show more than a 50% increase in conductivity in difference imaging as the result of this excitation. The change for samples without AuNPs is 40%. MDPI 2019-11-01 /pmc/articles/PMC6864618/ /pubmed/31683843 http://dx.doi.org/10.3390/s19214750 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Neshatvar, Nazanin
Damaso, Rui
Seifnaraghi, Nima
Demosthenous, Andreas
Bayford, Richard
Towards a System for Tracking Drug Delivery Using Frequency Excited Gold Nanoparticles
title Towards a System for Tracking Drug Delivery Using Frequency Excited Gold Nanoparticles
title_full Towards a System for Tracking Drug Delivery Using Frequency Excited Gold Nanoparticles
title_fullStr Towards a System for Tracking Drug Delivery Using Frequency Excited Gold Nanoparticles
title_full_unstemmed Towards a System for Tracking Drug Delivery Using Frequency Excited Gold Nanoparticles
title_short Towards a System for Tracking Drug Delivery Using Frequency Excited Gold Nanoparticles
title_sort towards a system for tracking drug delivery using frequency excited gold nanoparticles
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6864618/
https://www.ncbi.nlm.nih.gov/pubmed/31683843
http://dx.doi.org/10.3390/s19214750
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