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Scope and Limitations of γ-Valerolactone (GVL) as a Green Solvent to be Used with Base for Fmoc Removal in Solid Phase Peptide Synthesis

GVL is a green solvent used in Fmoc-based solid-phase peptide synthesis. It is susceptible to ring opening in the presence of bases such as piperidines, which are used to remove the Fmoc protecting group. Here we studied the formation of the corresponding acyl piperidides by time-dependent monitorin...

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Detalles Bibliográficos
Autores principales:	Kumar, Ashish, Sharma, Anamika, de la Torre, Beatriz G., Albericio, Fernando
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6864637/ https://www.ncbi.nlm.nih.gov/pubmed/31694279 http://dx.doi.org/10.3390/molecules24214004

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