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Recent Advances in the Discovery of Novel Antiprotozoal Agents
Parasitic diseases have serious health, social, and economic impacts, especially in the tropical regions of the world. Diseases caused by protozoan parasites are responsible for considerable mortality and morbidity, affecting more than 500 million people worldwide. Globally, the burden of protozoan...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6864685/ https://www.ncbi.nlm.nih.gov/pubmed/31661934 http://dx.doi.org/10.3390/molecules24213886 |
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author | Lee, Seong-Min Kim, Min-Sun Hayat, Faisal Shin, Dongyun |
author_facet | Lee, Seong-Min Kim, Min-Sun Hayat, Faisal Shin, Dongyun |
author_sort | Lee, Seong-Min |
collection | PubMed |
description | Parasitic diseases have serious health, social, and economic impacts, especially in the tropical regions of the world. Diseases caused by protozoan parasites are responsible for considerable mortality and morbidity, affecting more than 500 million people worldwide. Globally, the burden of protozoan diseases is increasing and is been exacerbated because of a lack of effective medication due to the drug resistance and toxicity of current antiprotozoal agents. These limitations have prompted many researchers to search for new drugs against protozoan parasites. In this review, we have compiled the latest information (2012–2017) on the structures and pharmacological activities of newly developed organic compounds against five major protozoan diseases, giardiasis, leishmaniasis, malaria, trichomoniasis, and trypanosomiasis, with the aim of showing recent advances in the discovery of new antiprotozoal drugs. |
format | Online Article Text |
id | pubmed-6864685 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-68646852019-12-23 Recent Advances in the Discovery of Novel Antiprotozoal Agents Lee, Seong-Min Kim, Min-Sun Hayat, Faisal Shin, Dongyun Molecules Review Parasitic diseases have serious health, social, and economic impacts, especially in the tropical regions of the world. Diseases caused by protozoan parasites are responsible for considerable mortality and morbidity, affecting more than 500 million people worldwide. Globally, the burden of protozoan diseases is increasing and is been exacerbated because of a lack of effective medication due to the drug resistance and toxicity of current antiprotozoal agents. These limitations have prompted many researchers to search for new drugs against protozoan parasites. In this review, we have compiled the latest information (2012–2017) on the structures and pharmacological activities of newly developed organic compounds against five major protozoan diseases, giardiasis, leishmaniasis, malaria, trichomoniasis, and trypanosomiasis, with the aim of showing recent advances in the discovery of new antiprotozoal drugs. MDPI 2019-10-28 /pmc/articles/PMC6864685/ /pubmed/31661934 http://dx.doi.org/10.3390/molecules24213886 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Lee, Seong-Min Kim, Min-Sun Hayat, Faisal Shin, Dongyun Recent Advances in the Discovery of Novel Antiprotozoal Agents |
title | Recent Advances in the Discovery of Novel Antiprotozoal Agents |
title_full | Recent Advances in the Discovery of Novel Antiprotozoal Agents |
title_fullStr | Recent Advances in the Discovery of Novel Antiprotozoal Agents |
title_full_unstemmed | Recent Advances in the Discovery of Novel Antiprotozoal Agents |
title_short | Recent Advances in the Discovery of Novel Antiprotozoal Agents |
title_sort | recent advances in the discovery of novel antiprotozoal agents |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6864685/ https://www.ncbi.nlm.nih.gov/pubmed/31661934 http://dx.doi.org/10.3390/molecules24213886 |
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