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Preserved network functional connectivity underlies cognitive reserve in multiple sclerosis
Cognitive reserve is one's mental resilience or resistance to the effects of structural brain damage. Reserve effects are well established in people with multiple sclerosis (PwMS) and Alzheimer's disease, but the neural basis of this phenomenon is unclear. We aimed to investigate whether p...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Inc.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6864900/ https://www.ncbi.nlm.nih.gov/pubmed/31444887 http://dx.doi.org/10.1002/hbm.24768 |
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author | Fuchs, Tom A. Benedict, Ralph H. B. Bartnik, Alexander Choudhery, Sanjeevani Li, Xian Mallory, Matthew Oship, Devon Yasin, Faizan Ashton, Kira Jakimovski, Dejan Bergsland, Niels Ramasamy, Deepa P. Weinstock‐Guttman, Bianca Zivadinov, Robert Dwyer, Michael G. |
author_facet | Fuchs, Tom A. Benedict, Ralph H. B. Bartnik, Alexander Choudhery, Sanjeevani Li, Xian Mallory, Matthew Oship, Devon Yasin, Faizan Ashton, Kira Jakimovski, Dejan Bergsland, Niels Ramasamy, Deepa P. Weinstock‐Guttman, Bianca Zivadinov, Robert Dwyer, Michael G. |
author_sort | Fuchs, Tom A. |
collection | PubMed |
description | Cognitive reserve is one's mental resilience or resistance to the effects of structural brain damage. Reserve effects are well established in people with multiple sclerosis (PwMS) and Alzheimer's disease, but the neural basis of this phenomenon is unclear. We aimed to investigate whether preservation of functional connectivity explains cognitive reserve. Seventy‐four PwMS and 29 HCs underwent neuropsychological assessment and 3 T MRI. Structural damage measures included gray matter (GM) atrophy and network white matter (WM) tract disruption between pairs of GM regions. Resting‐state functional connectivity was also assessed. PwMS exhibited significantly impaired cognitive processing speed (t = 2.14, p = .037) and visual/spatial memory (t = 2.72, p = .008), and had significantly greater variance in functional connectivity relative to HCs within relevant networks (p < .001, p < .001, p = .016). Higher premorbid verbal intelligence, a proxy for cognitive reserve, predicted relative preservation of functional connectivity despite accumulation of GM atrophy (standardized‐β = .301, p = .021). Furthermore, preservation of functional connectivity attenuated the impact of structural network WM tract disruption on cognition (β = −.513, p = .001, for cognitive processing speed; β = −.209, p = .066, for visual/spatial memory). The data suggests that preserved functional connectivity explains cognitive reserve in PwMS, helping to maintain cognitive capacity despite structural damage. |
format | Online Article Text |
id | pubmed-6864900 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | John Wiley & Sons, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-68649002020-06-12 Preserved network functional connectivity underlies cognitive reserve in multiple sclerosis Fuchs, Tom A. Benedict, Ralph H. B. Bartnik, Alexander Choudhery, Sanjeevani Li, Xian Mallory, Matthew Oship, Devon Yasin, Faizan Ashton, Kira Jakimovski, Dejan Bergsland, Niels Ramasamy, Deepa P. Weinstock‐Guttman, Bianca Zivadinov, Robert Dwyer, Michael G. Hum Brain Mapp Research Articles Cognitive reserve is one's mental resilience or resistance to the effects of structural brain damage. Reserve effects are well established in people with multiple sclerosis (PwMS) and Alzheimer's disease, but the neural basis of this phenomenon is unclear. We aimed to investigate whether preservation of functional connectivity explains cognitive reserve. Seventy‐four PwMS and 29 HCs underwent neuropsychological assessment and 3 T MRI. Structural damage measures included gray matter (GM) atrophy and network white matter (WM) tract disruption between pairs of GM regions. Resting‐state functional connectivity was also assessed. PwMS exhibited significantly impaired cognitive processing speed (t = 2.14, p = .037) and visual/spatial memory (t = 2.72, p = .008), and had significantly greater variance in functional connectivity relative to HCs within relevant networks (p < .001, p < .001, p = .016). Higher premorbid verbal intelligence, a proxy for cognitive reserve, predicted relative preservation of functional connectivity despite accumulation of GM atrophy (standardized‐β = .301, p = .021). Furthermore, preservation of functional connectivity attenuated the impact of structural network WM tract disruption on cognition (β = −.513, p = .001, for cognitive processing speed; β = −.209, p = .066, for visual/spatial memory). The data suggests that preserved functional connectivity explains cognitive reserve in PwMS, helping to maintain cognitive capacity despite structural damage. John Wiley & Sons, Inc. 2019-08-24 /pmc/articles/PMC6864900/ /pubmed/31444887 http://dx.doi.org/10.1002/hbm.24768 Text en © 2019 The Authors. Human Brain Mapping published by Wiley Periodicals, Inc. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Research Articles Fuchs, Tom A. Benedict, Ralph H. B. Bartnik, Alexander Choudhery, Sanjeevani Li, Xian Mallory, Matthew Oship, Devon Yasin, Faizan Ashton, Kira Jakimovski, Dejan Bergsland, Niels Ramasamy, Deepa P. Weinstock‐Guttman, Bianca Zivadinov, Robert Dwyer, Michael G. Preserved network functional connectivity underlies cognitive reserve in multiple sclerosis |
title | Preserved network functional connectivity underlies cognitive reserve in multiple sclerosis |
title_full | Preserved network functional connectivity underlies cognitive reserve in multiple sclerosis |
title_fullStr | Preserved network functional connectivity underlies cognitive reserve in multiple sclerosis |
title_full_unstemmed | Preserved network functional connectivity underlies cognitive reserve in multiple sclerosis |
title_short | Preserved network functional connectivity underlies cognitive reserve in multiple sclerosis |
title_sort | preserved network functional connectivity underlies cognitive reserve in multiple sclerosis |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6864900/ https://www.ncbi.nlm.nih.gov/pubmed/31444887 http://dx.doi.org/10.1002/hbm.24768 |
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