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Metabolic tumor volume predicts overall survival in patients with primary pulmonary lymphoepithelioma-like carcinoma
Pretreatment tumor metabolic burden, measured using fluorine-18 fluorodeoxyglucose positron emission tomography/computerized tomography ((18)F-FDG PET/CT), has been demonstrated to predict outcomes in various types of malignancies. Additionally, Epstein-Barr virus (EBV) serum titer is associated wit...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6864931/ https://www.ncbi.nlm.nih.gov/pubmed/31788088 http://dx.doi.org/10.3892/ol.2019.10954 |
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author | Lin, Chun-Yu Chang, Yu-Chuan Wang, I-Ting Hsieh, Meng-Heng Wang, Chih-Wei Lin, Shu-Min Wu, Ching-Yang Fang, Yueh-Fu |
author_facet | Lin, Chun-Yu Chang, Yu-Chuan Wang, I-Ting Hsieh, Meng-Heng Wang, Chih-Wei Lin, Shu-Min Wu, Ching-Yang Fang, Yueh-Fu |
author_sort | Lin, Chun-Yu |
collection | PubMed |
description | Pretreatment tumor metabolic burden, measured using fluorine-18 fluorodeoxyglucose positron emission tomography/computerized tomography ((18)F-FDG PET/CT), has been demonstrated to predict outcomes in various types of malignancies. Additionally, Epstein-Barr virus (EBV) serum titer is associated with stages of pulmonary lymphoepithelioma-like carcinoma (LELC). The present study aimed to investigate the prognostic value of the functional parameters of (18)F-FDG PET/CT in pulmonary LELC and their association with serum EBV DNA. The present retrospective study analyzed data from 71 patients with pulmonary LELC; among these, 32 patients with pulmonary LELC underwent pretreatment (18)F-FDG PET/CT staging between January 2008 and December 2016. EBV viral load and functional parameters of (18)F-FDG PET/CT were used for survival analysis. Multivariate analysis identified tumor stage IV as a significant predictor of poor progression-free survival [hazard ratio (HR), 4.85; P=0.049], whereas elevated total metabolic tumor volume (MTV ≥72.6 ml) independently predicted worse overall survival (OS; HR, 12.59; P=0.024). Pretreatment serum EBV DNA titer was significantly positively associated with total MTV (P=0.0337) and total lesion glycolysis (TLG; P=0.0093), but could not predict outcomes. Total MTV was an independent predictor of OS, and may guide clinical management for pulmonary LELC. |
format | Online Article Text |
id | pubmed-6864931 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-68649312019-11-30 Metabolic tumor volume predicts overall survival in patients with primary pulmonary lymphoepithelioma-like carcinoma Lin, Chun-Yu Chang, Yu-Chuan Wang, I-Ting Hsieh, Meng-Heng Wang, Chih-Wei Lin, Shu-Min Wu, Ching-Yang Fang, Yueh-Fu Oncol Lett Articles Pretreatment tumor metabolic burden, measured using fluorine-18 fluorodeoxyglucose positron emission tomography/computerized tomography ((18)F-FDG PET/CT), has been demonstrated to predict outcomes in various types of malignancies. Additionally, Epstein-Barr virus (EBV) serum titer is associated with stages of pulmonary lymphoepithelioma-like carcinoma (LELC). The present study aimed to investigate the prognostic value of the functional parameters of (18)F-FDG PET/CT in pulmonary LELC and their association with serum EBV DNA. The present retrospective study analyzed data from 71 patients with pulmonary LELC; among these, 32 patients with pulmonary LELC underwent pretreatment (18)F-FDG PET/CT staging between January 2008 and December 2016. EBV viral load and functional parameters of (18)F-FDG PET/CT were used for survival analysis. Multivariate analysis identified tumor stage IV as a significant predictor of poor progression-free survival [hazard ratio (HR), 4.85; P=0.049], whereas elevated total metabolic tumor volume (MTV ≥72.6 ml) independently predicted worse overall survival (OS; HR, 12.59; P=0.024). Pretreatment serum EBV DNA titer was significantly positively associated with total MTV (P=0.0337) and total lesion glycolysis (TLG; P=0.0093), but could not predict outcomes. Total MTV was an independent predictor of OS, and may guide clinical management for pulmonary LELC. D.A. Spandidos 2019-12 2019-10-02 /pmc/articles/PMC6864931/ /pubmed/31788088 http://dx.doi.org/10.3892/ol.2019.10954 Text en Copyright: © Lin et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
spellingShingle | Articles Lin, Chun-Yu Chang, Yu-Chuan Wang, I-Ting Hsieh, Meng-Heng Wang, Chih-Wei Lin, Shu-Min Wu, Ching-Yang Fang, Yueh-Fu Metabolic tumor volume predicts overall survival in patients with primary pulmonary lymphoepithelioma-like carcinoma |
title | Metabolic tumor volume predicts overall survival in patients with primary pulmonary lymphoepithelioma-like carcinoma |
title_full | Metabolic tumor volume predicts overall survival in patients with primary pulmonary lymphoepithelioma-like carcinoma |
title_fullStr | Metabolic tumor volume predicts overall survival in patients with primary pulmonary lymphoepithelioma-like carcinoma |
title_full_unstemmed | Metabolic tumor volume predicts overall survival in patients with primary pulmonary lymphoepithelioma-like carcinoma |
title_short | Metabolic tumor volume predicts overall survival in patients with primary pulmonary lymphoepithelioma-like carcinoma |
title_sort | metabolic tumor volume predicts overall survival in patients with primary pulmonary lymphoepithelioma-like carcinoma |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6864931/ https://www.ncbi.nlm.nih.gov/pubmed/31788088 http://dx.doi.org/10.3892/ol.2019.10954 |
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