Trash to Treasure: Eco-Friendly and Practical Synthesis of Amides by Nitriles Hydrolysis in WEPPA

The hydration of nitriles to amides in a water extract of pomelo peel ash (WEPPA) was realized with moderate to excellent yields without using external transition metals, bases or organic solvents. This reaction features a broad substrate scope, wide functional group tolerance, prominent chemoselect...

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Detalles Bibliográficos
Autores principales: Sun, Yajun, Jin, Weiwei, Liu, Chenjiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6864965/
https://www.ncbi.nlm.nih.gov/pubmed/31653123
http://dx.doi.org/10.3390/molecules24213838
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author Sun, Yajun
Jin, Weiwei
Liu, Chenjiang
author_facet Sun, Yajun
Jin, Weiwei
Liu, Chenjiang
author_sort Sun, Yajun
collection PubMed
description The hydration of nitriles to amides in a water extract of pomelo peel ash (WEPPA) was realized with moderate to excellent yields without using external transition metals, bases or organic solvents. This reaction features a broad substrate scope, wide functional group tolerance, prominent chemoselectivity, and good reusability. Notably, a magnification experiment in this bio-based solvent at 100 mmol further demonstrated its practicability.
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spelling pubmed-68649652019-12-06 Trash to Treasure: Eco-Friendly and Practical Synthesis of Amides by Nitriles Hydrolysis in WEPPA Sun, Yajun Jin, Weiwei Liu, Chenjiang Molecules Article The hydration of nitriles to amides in a water extract of pomelo peel ash (WEPPA) was realized with moderate to excellent yields without using external transition metals, bases or organic solvents. This reaction features a broad substrate scope, wide functional group tolerance, prominent chemoselectivity, and good reusability. Notably, a magnification experiment in this bio-based solvent at 100 mmol further demonstrated its practicability. MDPI 2019-10-24 /pmc/articles/PMC6864965/ /pubmed/31653123 http://dx.doi.org/10.3390/molecules24213838 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Sun, Yajun
Jin, Weiwei
Liu, Chenjiang
Trash to Treasure: Eco-Friendly and Practical Synthesis of Amides by Nitriles Hydrolysis in WEPPA
title Trash to Treasure: Eco-Friendly and Practical Synthesis of Amides by Nitriles Hydrolysis in WEPPA
title_full Trash to Treasure: Eco-Friendly and Practical Synthesis of Amides by Nitriles Hydrolysis in WEPPA
title_fullStr Trash to Treasure: Eco-Friendly and Practical Synthesis of Amides by Nitriles Hydrolysis in WEPPA
title_full_unstemmed Trash to Treasure: Eco-Friendly and Practical Synthesis of Amides by Nitriles Hydrolysis in WEPPA
title_short Trash to Treasure: Eco-Friendly and Practical Synthesis of Amides by Nitriles Hydrolysis in WEPPA
title_sort trash to treasure: eco-friendly and practical synthesis of amides by nitriles hydrolysis in weppa
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6864965/
https://www.ncbi.nlm.nih.gov/pubmed/31653123
http://dx.doi.org/10.3390/molecules24213838
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AT liuchenjiang trashtotreasureecofriendlyandpracticalsynthesisofamidesbynitrileshydrolysisinweppa

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