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Antileukemic Activity of Twig Components of Caucasian Beech in Turkey

Despite the development of a range of anti-cancer agents, cancer diagnoses are still increasing in number, remaining a leading cause of death. Anticancer drug treatment is particularly important for leukemia. We screened Turkish plants and found the unique antileukemic activity of twig components in...

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Autores principales: Shida, Wataru, Tateishi, Hiroshi, Tahara, Yurika, Fujita, Mikako, Husham Majeed Alsaadi, Doaa, Watanabe, Masato, Koga, Ryoko, Radwan, Mohamed O., Ciftci, Halil I., Gezici, Sevgi, Kurauchi, Yuki, Katsuki, Hiroshi, Otsuka, Masami, Sugimura, Koji, Wada, Mikiyo, Sekeroglu, Nazim, Watanabe, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6864984/
https://www.ncbi.nlm.nih.gov/pubmed/31731511
http://dx.doi.org/10.3390/molecules24213850
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author Shida, Wataru
Tateishi, Hiroshi
Tahara, Yurika
Fujita, Mikako
Husham Majeed Alsaadi, Doaa
Watanabe, Masato
Koga, Ryoko
Radwan, Mohamed O.
Ciftci, Halil I.
Gezici, Sevgi
Kurauchi, Yuki
Katsuki, Hiroshi
Otsuka, Masami
Sugimura, Koji
Wada, Mikiyo
Sekeroglu, Nazim
Watanabe, Takashi
author_facet Shida, Wataru
Tateishi, Hiroshi
Tahara, Yurika
Fujita, Mikako
Husham Majeed Alsaadi, Doaa
Watanabe, Masato
Koga, Ryoko
Radwan, Mohamed O.
Ciftci, Halil I.
Gezici, Sevgi
Kurauchi, Yuki
Katsuki, Hiroshi
Otsuka, Masami
Sugimura, Koji
Wada, Mikiyo
Sekeroglu, Nazim
Watanabe, Takashi
author_sort Shida, Wataru
collection PubMed
description Despite the development of a range of anti-cancer agents, cancer diagnoses are still increasing in number, remaining a leading cause of death. Anticancer drug treatment is particularly important for leukemia. We screened Turkish plants and found the unique antileukemic activity of twig components in Turkish Caucasian beech, selectively inducing apoptosis in leukemia cells. This effect is unique among some kinds of beeches, presumably related to oxidative stress. This study would lead to effective use of discarded material, i.e., twig of beech, and a new anti-leukemic drug based on large tree.
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spelling pubmed-68649842019-12-06 Antileukemic Activity of Twig Components of Caucasian Beech in Turkey Shida, Wataru Tateishi, Hiroshi Tahara, Yurika Fujita, Mikako Husham Majeed Alsaadi, Doaa Watanabe, Masato Koga, Ryoko Radwan, Mohamed O. Ciftci, Halil I. Gezici, Sevgi Kurauchi, Yuki Katsuki, Hiroshi Otsuka, Masami Sugimura, Koji Wada, Mikiyo Sekeroglu, Nazim Watanabe, Takashi Molecules Communication Despite the development of a range of anti-cancer agents, cancer diagnoses are still increasing in number, remaining a leading cause of death. Anticancer drug treatment is particularly important for leukemia. We screened Turkish plants and found the unique antileukemic activity of twig components in Turkish Caucasian beech, selectively inducing apoptosis in leukemia cells. This effect is unique among some kinds of beeches, presumably related to oxidative stress. This study would lead to effective use of discarded material, i.e., twig of beech, and a new anti-leukemic drug based on large tree. MDPI 2019-10-25 /pmc/articles/PMC6864984/ /pubmed/31731511 http://dx.doi.org/10.3390/molecules24213850 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Shida, Wataru
Tateishi, Hiroshi
Tahara, Yurika
Fujita, Mikako
Husham Majeed Alsaadi, Doaa
Watanabe, Masato
Koga, Ryoko
Radwan, Mohamed O.
Ciftci, Halil I.
Gezici, Sevgi
Kurauchi, Yuki
Katsuki, Hiroshi
Otsuka, Masami
Sugimura, Koji
Wada, Mikiyo
Sekeroglu, Nazim
Watanabe, Takashi
Antileukemic Activity of Twig Components of Caucasian Beech in Turkey
title Antileukemic Activity of Twig Components of Caucasian Beech in Turkey
title_full Antileukemic Activity of Twig Components of Caucasian Beech in Turkey
title_fullStr Antileukemic Activity of Twig Components of Caucasian Beech in Turkey
title_full_unstemmed Antileukemic Activity of Twig Components of Caucasian Beech in Turkey
title_short Antileukemic Activity of Twig Components of Caucasian Beech in Turkey
title_sort antileukemic activity of twig components of caucasian beech in turkey
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6864984/
https://www.ncbi.nlm.nih.gov/pubmed/31731511
http://dx.doi.org/10.3390/molecules24213850
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