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Peritumoral administration of DRibbles-pulsed antigen-presenting cells enhances the antitumor efficacy of anti-GITR and anti-PD-1 antibodies via an antigen presenting independent mechanism

BACKGROUND: TNF receptor family agonists and checkpoint blockade combination therapies lead to minimal tumor clearance of poorly immunogenic tumors. Therefore, a need to enhance the efficacy of this combination therapy arises. Antigen-presenting cells (APCs) present antigen to T cells and steer the...

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Detalles Bibliográficos
Autores principales:	Patel, Jaina M., Cui, Zhihua, Wen, Zhi-Fa, Dinh, Catherine T., Hu, Hong-Ming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6865022/ https://www.ncbi.nlm.nih.gov/pubmed/31747946 http://dx.doi.org/10.1186/s40425-019-0786-7

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