Cargando…

Adverse Drug Reaction (ADR) as a Cause of Hospitalization at a Government Hospital in Saudi Arabia: A Prospective Observational Study

BACKGROUND: ADRs represent a substantial burden on health care resources worldwide and are considered as one of the leading causes of morbidity and mortality which significantly affects hospitalization rates. However, ADR related hospital admissions are not well explored in Saudi Arabia. OBJECTIVE:...

Descripción completa

Detalles Bibliográficos
Autores principales: Alayed, Nouf, Alkhalifah, Bushra, Alharbi, Munirah, Alwohaibi, Naief, Farooqui, Maryam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Science Publishers 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6865052/
https://www.ncbi.nlm.nih.gov/pubmed/31109277
http://dx.doi.org/10.2174/1574886314666190520105330
_version_ 1783472019078119424
author Alayed, Nouf
Alkhalifah, Bushra
Alharbi, Munirah
Alwohaibi, Naief
Farooqui, Maryam
author_facet Alayed, Nouf
Alkhalifah, Bushra
Alharbi, Munirah
Alwohaibi, Naief
Farooqui, Maryam
author_sort Alayed, Nouf
collection PubMed
description BACKGROUND: ADRs represent a substantial burden on health care resources worldwide and are considered as one of the leading causes of morbidity and mortality which significantly affects hospitalization rates. However, ADR related hospital admissions are not well explored in Saudi Arabia. OBJECTIVE: The current study aims to evaluate ADR-related admissions at King Saud Hospital, Unaizah, Qassim, Saudi Arabia. METHODS: A prospective, observational study was conducted at King Saud Hospital Unaizah. Over a period of 6 months, patients above 12 years of age who visited the Emergency Department (ED) with an ADR were included in this study. The investigators collected patient data by reviewing the patient's medical records and the ED records for admission. The Naranjo algorithm was used to assess the causality of the suspected ADR, and Hartwig’s Severity Assessment Scale was used to assess the severity of the ADR. RESULTS: Out of 4739 admissions to the wards, 38 (0.801%) were related to an ADR. The majority of patients were male (52.6%), with a mean age of ± 49.08 years. The total length of hospital stay was 565 days with a mean of ± 14.87 days. The causality assessment shows that 35 (92.1%) cases were probable ADRs, whereas 3 (7.9%) cases were possible ADRs. Moreover, the severity assessment showed that 6 (15.1%) cases were mild, and 27 (71.1%) and 5 (13.2%) cases were moderate and severe, respectively. In regard to the outcome of patients, most patients recovered after the ADR, and 2 ADRs resulted in the death of the patient. CONCLUSION: Our study shows that ADRs as a cause of hospitalization in Qassim population is considerably low. However, ADRs may contribute to morbidity and mortality and result in a considerable financial burden.
format Online
Article
Text
id pubmed-6865052
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Bentham Science Publishers
record_format MEDLINE/PubMed
spelling pubmed-68650522020-01-02 Adverse Drug Reaction (ADR) as a Cause of Hospitalization at a Government Hospital in Saudi Arabia: A Prospective Observational Study Alayed, Nouf Alkhalifah, Bushra Alharbi, Munirah Alwohaibi, Naief Farooqui, Maryam Curr Drug Saf Article BACKGROUND: ADRs represent a substantial burden on health care resources worldwide and are considered as one of the leading causes of morbidity and mortality which significantly affects hospitalization rates. However, ADR related hospital admissions are not well explored in Saudi Arabia. OBJECTIVE: The current study aims to evaluate ADR-related admissions at King Saud Hospital, Unaizah, Qassim, Saudi Arabia. METHODS: A prospective, observational study was conducted at King Saud Hospital Unaizah. Over a period of 6 months, patients above 12 years of age who visited the Emergency Department (ED) with an ADR were included in this study. The investigators collected patient data by reviewing the patient's medical records and the ED records for admission. The Naranjo algorithm was used to assess the causality of the suspected ADR, and Hartwig’s Severity Assessment Scale was used to assess the severity of the ADR. RESULTS: Out of 4739 admissions to the wards, 38 (0.801%) were related to an ADR. The majority of patients were male (52.6%), with a mean age of ± 49.08 years. The total length of hospital stay was 565 days with a mean of ± 14.87 days. The causality assessment shows that 35 (92.1%) cases were probable ADRs, whereas 3 (7.9%) cases were possible ADRs. Moreover, the severity assessment showed that 6 (15.1%) cases were mild, and 27 (71.1%) and 5 (13.2%) cases were moderate and severe, respectively. In regard to the outcome of patients, most patients recovered after the ADR, and 2 ADRs resulted in the death of the patient. CONCLUSION: Our study shows that ADRs as a cause of hospitalization in Qassim population is considerably low. However, ADRs may contribute to morbidity and mortality and result in a considerable financial burden. Bentham Science Publishers 2019-11 2019-11 /pmc/articles/PMC6865052/ /pubmed/31109277 http://dx.doi.org/10.2174/1574886314666190520105330 Text en © 2019 Bentham Science Publishers https://creativecommons.org/licenses/by-nc/4.0/legalcode This is an open access article licensed under the terms of the Creative Commons Attribution-Non-Commercial 4.0 International Public License (CC BY-NC 4.0) (https://creativecommons.org/licenses/by-nc/4.0/legalcode), which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
spellingShingle Article
Alayed, Nouf
Alkhalifah, Bushra
Alharbi, Munirah
Alwohaibi, Naief
Farooqui, Maryam
Adverse Drug Reaction (ADR) as a Cause of Hospitalization at a Government Hospital in Saudi Arabia: A Prospective Observational Study
title Adverse Drug Reaction (ADR) as a Cause of Hospitalization at a Government Hospital in Saudi Arabia: A Prospective Observational Study
title_full Adverse Drug Reaction (ADR) as a Cause of Hospitalization at a Government Hospital in Saudi Arabia: A Prospective Observational Study
title_fullStr Adverse Drug Reaction (ADR) as a Cause of Hospitalization at a Government Hospital in Saudi Arabia: A Prospective Observational Study
title_full_unstemmed Adverse Drug Reaction (ADR) as a Cause of Hospitalization at a Government Hospital in Saudi Arabia: A Prospective Observational Study
title_short Adverse Drug Reaction (ADR) as a Cause of Hospitalization at a Government Hospital in Saudi Arabia: A Prospective Observational Study
title_sort adverse drug reaction (adr) as a cause of hospitalization at a government hospital in saudi arabia: a prospective observational study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6865052/
https://www.ncbi.nlm.nih.gov/pubmed/31109277
http://dx.doi.org/10.2174/1574886314666190520105330
work_keys_str_mv AT alayednouf adversedrugreactionadrasacauseofhospitalizationatagovernmenthospitalinsaudiarabiaaprospectiveobservationalstudy
AT alkhalifahbushra adversedrugreactionadrasacauseofhospitalizationatagovernmenthospitalinsaudiarabiaaprospectiveobservationalstudy
AT alharbimunirah adversedrugreactionadrasacauseofhospitalizationatagovernmenthospitalinsaudiarabiaaprospectiveobservationalstudy
AT alwohaibinaief adversedrugreactionadrasacauseofhospitalizationatagovernmenthospitalinsaudiarabiaaprospectiveobservationalstudy
AT farooquimaryam adversedrugreactionadrasacauseofhospitalizationatagovernmenthospitalinsaudiarabiaaprospectiveobservationalstudy