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IL6 receptor(358)Ala variant and trans-signaling are disease modifiers in amyotrophic lateral sclerosis

OBJECTIVE: To test the hypothesis that patients with amyotrophic lateral sclerosis (ALS) inheriting the common interleukin 6 receptor (IL6R) coding variant (Asp(358)Ala, rs2228145, C allele) have associated increases in interleukin 6 (IL6) and IL6R levels in serum and CSF and faster disease progress...

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Detalles Bibliográficos
Autores principales:	Wosiski-Kuhn, Marlena, Robinson, Mac, Strupe, Jane, Arounleut, Phonepasong, Martin, Matthew, Caress, James, Cartwright, Michael, Bowser, Robert, Cudkowicz, Merit, Langefeld, Carl, Hawkins, Gregory A., Milligan, Carol
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Lippincott Williams & Wilkins 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6865852/ https://www.ncbi.nlm.nih.gov/pubmed/31611269 http://dx.doi.org/10.1212/NXI.0000000000000631

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