Constitutive AKT Activity Predisposes Lung Fibrosis by Regulating Macrophage, Myofibroblast and Fibrocyte Recruitment and Changes in Autophagy

The etiology and pathogenesis of pulmonary fibrosis is poorly understood. We and others reported that M-CSF/CSF-1, M-CSF-R and downstream AKT activation plays an important role in lung fibrosis in mice models and in IPF patients. To understand potential molecular pathways used by M-CSF-R activation...

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Detalles Bibliográficos
Autores principales: Dakhlallah, Duaa, Wang, Yijie, Bobo, Tierra A., Ellis, Emily, Mo, Xiaokui, Piper, Melissa G., Eubank, Timothy D., Marsh, Clay B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6866236/
https://www.ncbi.nlm.nih.gov/pubmed/31750010
http://dx.doi.org/10.4236/abb.2019.1010027

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