Developmental Toxicity Assessment of Piperonyl Butoxide Exposure Targeting Sonic Hedgehog Signaling and Forebrain and Face Morphogenesis in the Mouse: An in Vitro and in Vivo Study

BACKGROUND: Piperonyl butoxide (PBO) is a pesticide synergist used in residential, commercial, and agricultural settings. PBO was recently found to inhibit Sonic hedgehog (Shh) signaling, a key developmental regulatory pathway. Disruption of Shh signaling is linked to birth defects, including holopr...

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Detalles Bibliográficos
Autores principales: Everson, Joshua L., Sun, Miranda R., Fink, Dustin M., Heyne, Galen W., Melberg, Cal G., Nelson, Kia F., Doroodchi, Padydeh, Colopy, Lydia J., Ulschmid, Caden M., Martin, Alexander A., McLaughlin, Matthew T., Lipinski, Robert J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Environmental Health Perspectives 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6867268/
https://www.ncbi.nlm.nih.gov/pubmed/31642701
http://dx.doi.org/10.1289/EHP5260

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